STAR multivalent growth factor human FGF2
STAR technology presents multiple growth factors as connected entities to generate biological activity orders of magnitude higher than standard growth factors. STAR growth factors generate both higher levels of efficiency (reduced amounts required to achieve the same outcome) and greater efficacy (extent of effect achievable). Typically 10-100 fold increases in activity are achieved. STAR growth factors are STAR growth factors are highly cost effective providing superior control over cell populations at markedly lower costs.
Fibroblast proliferation dose response curve. STAR H FGF2 consistently out-performs FGF2 from leading competitors. STAR H FGF2 achieves higher peak levels of stimulation (increased efficacy) using lower concentrations (increased efficiency). A commercial assay was used to quantitate cell numbers which are expressed as relative fluorescence units (RFU). Two separate lots of STAR H FGF2 (green and blue lines) were compared against FGF2 from leading competitors P (red) and I (black) at concentrations ranging from 0.01ng/ml to 100ng/ml. 9-100 fold concentrations of competitor FGF2 were required to generate the same proliferation rates as STAR H FGF2. Moreover, maximal stimulation for STAR H FGF2 (of 85-93 RFU) was achieved at a concentration of 10ng/ml. In contrast, competitor FGF2 achieved maximal stimulation of 66-68 RFU at a concentrations of 10ng and 50ng/ml respectively.
STARTM H FGF2 outperforms standard FGF2 across a range of sera concentrations. A commercial assay was used to quantitate fibroblast cell numbers which are expressed as relative fluorescence units (RFU). STARTM H FGF2 (red line) were compared against FGF2 from a leading competitor I (green). The concentration of each growth factor was held at 10ng/ml and the concentration of sera was varied between 0-10%. At each serum concentration, the proliferation response achieved with STARTM H FGF2 was significantly higher than achieved with competitor products.
In comparison with widely used growth factors, STAR growth factors generate superior results at concentrations typically around 10-100 fold lower. This huge increase in performance is generated by a novel, hyaluronic acid containing, multivalent structure.
Schematic of STAR molecule structure and multiple receptor binding
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