Recombinant Rat IL-17E / IL-25

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Description

Interleukin-17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17BR receptor to stimulate the secretion of the proinflammatory Interleukin-8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).

Activity Assay

Rat IL-17E is fully biologically active when compared to standard. The activity is determined by the ability to produce human IL-8 by human PBMC cells.

AA Sequence

MCSHLPRCCP SKQQEFPEEW LKWNPAPVSP PEPLRHTHHP ESCRASKDGP LNSRAISPWS YELDRDLNRV PQDLYHARCL CPHCVSLQTG SHMDPMGNSV PLYHNQTVFY RRPCHGEQGA HGRYCLERRL YRVSLACVCV RPRMMA

Alternative Names

Interleukin-17E, interleukin 17E, IL17E, IL 17E, Interleukin-25, interleukin 25, IL25, IL 25, IL-25
Product Details
Length 146 / 292 aa
Molecular Weight 16.9 / 33.8 kDa
Structure Dimer
Source E. coli
Accession Number D3ZLB1
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.