Recombinant Mouse IL-17F

Code Description Price Qty
GFM62-5 Mouse IL-17F, 5 μg $75.00
GFM62-25 Mouse IL-17F, 25 μg $189.00
GFM62-100 Mouse IL-17F, 100 μg $469.00
GFM62-1000 Mouse IL-17F, 1 mg $3,382.00
Induced production of mouse IL-6 by NIH-3T3 cells. Production of mouse IL-6 was measured to calculate the ED50.

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Description

Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).

Activity Assay

Mouse IL-17F is fully biologically active when compared to standard. The activity is determined by the ability to produce mouse IL-6 by NIH-3T3 cells.

AA Sequence

MRKNPKAGVP ALQKAGNCPP LEDNTVRVDI RIFNQNQGIS VPREFQNRSS SPWDYNITRD PHRFPSEIAE AQCRHSGCIN AQGQEDSTMN SVAIQQEILV LRREPQGCSN SFRLEKMLLK VGCTCVKPIV HQAA

Alternative Names

Interleukin-17F, interleukin 17F, IL17F, IL 17F
Product Details
Length 134 / 268 aa
Molecular Weight 15.0 / 30.0 kDa
Structure Dimer
Source E. coli
Accession Number Q7TNI7
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.