Purmorphamine
Purmorphamine
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
Purmorphamine is an agonist of the protein Smoothened (Hh), a key part of the hedgehog signaling pathway, which is involved in bone growth and brain development as well as having a number of other functions in the body.
Effect
Purmorphamine has been shown to induce osteogenesis in bone tissue as well as influencing growth and differentiation of neurons in the brain. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 µM.
Alternative Names
9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen-1-yloxy)-9H-purin-6-amine 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
References
1. Xu, X., et al. 2004. Chem Biol. 11(9): 1229-1238. PMID: 15380183
| Product Details | |
|---|---|
| Formula | C31H32N6O2 |
| Molecular Weight | 520.6 |
| CAS Number | 483367-10-8 |
| Purity | >98% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
