CHIR99021

Code Description Price Qty
SM13-1 CHIR99021, 1 mg £25.00
SM13-5 CHIR99021, 5 mg £75.00
SM13-10 CHIR99021, 10 mg £135.00
SM13-50 CHIR99021, 50 mg £530.00
CHIR99021

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

CHIR99021 is an aminopyrimidine derivative. CHIR99021 inhibits GSK3 beta (IC50 = 6.7 nM) and GSK3 alpha (IC50 = 10 nM) and functions as a WNT pathway activator.

Effect

CHIR99021 is widely used in definitive endoderm differentiation protocols.

Alternative Names

CHIR-99021, CHIR 99021, CT 99021, CHIR 911, GSK-3 Inhibitor XVI

6-?[[2-?[[4-?(2,?4-?dichlorophenyl)-?5-?(5-?methyl-?1H-?imidazol-?2-?yl)-?2-?pyrimidinyl]amino]ethyl]amino]-?3-?pyridinecarbonitrile

References

1. Naujok, O., et al. 2014. BMC Res Notes. 7(1): 273. PMID: 24779365

2. Tsukiyama, T. and Ohinata, Y. 2014. PLoS One. 9(4): e95329. PMID: 24736627

Product Details
Formula C22H18Cl2N8
Molecular Weight 465.35
CAS Number 252917-06-9
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.