NVP-BEZ235

Code Description Price Qty
SM69-25 NVP-BEZ235, 25 mg $60.00
SM69-100 NVP-BEZ235, 100 mg $175.00
SM69-1000 NVP-BEZ235, 1 g $1,506.00
NVP-BEZ235

Activity

NVP-BEZ235 is a PI 3-kinase (PI3K) tyrosine kinase inhibitor and shows dual PI3K/mTOR inhibition. NVP-BEZ235 also inhibits ATR. However, NVP-BEZ235 has been shown to be poor inhibitory to Akt and PDK1.

Effect

NVP-BEZ235 shows high target specificity and demonstrates antiproliferative activity against tumor cell lines in animal models of cancer.

Alternative Names

BEZ235, Dactolisib

2-methyl-2-(4-(3-methyl-2-oxo-8-(quinolin-3-yl)-2,3-dihydroimidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile

References

1. Lyssiotis, CA., et al. 2011. Angew Chem Int Ed Engl. 50(1): 200-242. PMID: 21184400

2. Wang, WJ., et al. 2013. Acta Pharmacol Sin. 34(5): 681-690. PMID: 23603977

Product Details
Formula C30H23N5O
Molecular Weight 469.54
CAS Number 915019-65-7
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.