SB431542

Code Description Price Qty
SM33-2 SB431542, 2 mg £25.00
SM33-10 SB431542, 10 mg £75.00
SM33-50 SB431542, 50 mg £300.00
SM33-200 SB431542, 200 mg £925.00
SB431542

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

SB431542 is a potent and selective inhibitor of the TGF-β superfamily type 1 (TGF-β 1) activin receptor-like kinase (ALK5) receptors, and its relatives ALK4 and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6. SB431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

Effect

SB431542 suppresses TGF-β-induced proliferation of human osteosarcoma cells. SB431542 treatment of glioma cultures inhibited proliferation, TGF-β-mediated morphologic changes, and cellular motility. Small molecule inhibitors of TGF-β receptors may offer a novel therapy for malignant gliomas by reducing cell proliferation, angiogenesis, and motility.

Alternative Names

SB-431542, SB 431542

4-[4-(1,3-Benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide

References

1. Laping, NJ., et al. 2002. Mol Pharmacol. 62(1): 58-64. PMID: 12065755

2. Hjelmeland, MD., et al. 2004. Mol Cancer Ther. 3(6): 737-745. PMID: 15210860

3. Lei, Y. and Schaffer, DV. 2013. Proc Natl Acad Sci U S A. 110(52): E5039-5048. PMID: 24248365

Product Details
Formula C22H16N4O3
Molecular Weight 384.39
CAS Number 301836-41-9
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.