
Click the image to see the growing range of successfully cultured cells
Extensively validated in over 40 cell types, PeptiGel® is a family of defined, tunable, synthetic self-assembling peptide hydrogels (SAPHs) that provide a perfect canvas for 3D cell culture and bioprinting. Bespoke. Not one-size-fits-all, PeptiGel® hydrogel's fully defined components enable consistent product quality and reproducible results. This provides a tailored, better, kinder alternative to traditional animal-derived hydrogels.
Next-generation self-assembling peptide hydrogel (SAPHs)

Peptide stacks that form in PeptiGel develop 3D nano-fibrous matrix hydrogel networks
Tunable in two key ways

Click the image to see the growing range of successfully cultured cells
PeptiGel is a family of related hydrogels that provide a range of class-leading SAPHs and bioinks to support your cell culture applications. The proprietary hydrogel technology allows us to tune mechanical and functional properties, to provide you with the most suitable materials tailored to your application's needs. Firstly, the peptide backbone sequence is modified affecting properties such as charge. Secondly, motifs, such as RGD and GFOGER are fused to the backbone sequence completely interesting them into the hydrogel. This is not an admixture. Of course, PeptiGels may be diluted to optimize viscosity. You can be assured that PeptiGels® are physiological and biologically relevant hydrogels that mimic the cell micro-environment and provide a synthetic extracellular matrix.
Trial sizes for new users
Up to 5 different 1 ml packs may be purchased at an introductory price (see below) for evaluation with your culture system.
PeptiInk® for 3D bioprinting
Specifically designed to facilitate the 3D printing of cells. Available for Alpha 4 and Alpha 4 PLUS only.
Just a few of the cell types cultured with PeptiGel®

Examples of cells grown with PeptiGel® hydrogels. PDAC= pancreatic ductal adenocarcinoma, rOSFs = rat oesophageal stromal fibroblasts. For further details, please see the PeptiGel resources page.
PeptiGel® - What researchers say






Cell Compatibility
Gel type and demonstrated compatible cells
|
PeptiGel® Type
|
Charge
|
Stiffness (kPa)
|
Biomimetic Functionality
|
Demonstrated Compatible Primary Cells and Cell Lines
|
Alpha 1
|
Neutral |
3 - 5 |
None |
Adipose-derived stem cells, Chondrocytes, Dorsal root ganglion neurons, Breast MCF7, MCF10a, MDAMB231 and Breast EpH4, Schwann cells, Oesophageal, Fibroblast 3T3, Kidney HEK293, iPSCs, Ovary A2780 and SK-OV-3
|
Alpha 2 |
+1 |
6 - 8 |
None |
Adipose-derived stem cells, iPSC-derived cardiomyocytes, Chondrocytes, Dorsal root ganglion neurons, Liver HepG2, Pancreas Suit-2, Prostate PC3, Prostate pNT2, Ovary A2780 and SK-OV-3, Hepatic cells |
Alpha 2 Plus
|
+1 |
6 - 8 |
RGD & GFOGER |
in vivo Neuronal |
Alpha 4 |
+2 |
0.7 - 1.3 |
None |
Mammary epithelial, Bone marrow-derived stem cells, Dermal fibroblasts, Colon organoids, Kidney organoids, Synovial cells, iPSCs, Fibroblasts 3T3 + L929, Muscle C2C12, Ovary A2780 and SK-OV-3, HUVECS |
Alpha 4 Plus |
+2 |
0.7 - 1.3 |
RGD & GFOGER |
Stromal fibroblasts, Ovary A2780 and SK-OV-3, Colon crypts |
Alpha 8 |
-3 |
~ 0.25 |
None |
Hepatic Cells |
Delta 1 |
Neutral |
3 - 5 |
None |
Mesenchymal Stem Cells |
Gamma 2 |
+1 |
~ 1.5 |
None |
Dorsal root ganglion neurons, Pancreas Suit-2, Hepatic cells, iPSC |
Gamma 2 Plus |
+1 |
~ 2.5 |
RGD & GFOGER |
Neuronal |
Gamma 4 |
+2 |
0.175 - 0.35 |
None |
For cells requiring a softer environment, including primary cells, immortalized cells and stem cells |
Gamma 4 Plus |
+2 |
0.175 - 0.35 |
RGD & GFOGER |
Spheroids and organoids |
|
The stiffness values given here are indicative and have been measured by shear rheometry after 24 incubation in DMEM media.
Bespoke Peptide Hydrogel Design
The chemistry, mechanical and bio-functional properties of each PeptiGel® can be tuned to create bespoke products to suit your cells’ needs. This includes functionalizing a PeptiGel® with peptide sequences from collagen (GFOGER), fibronectin (RGD), & laminin (IKVAV or YIGSR). We can also tailor the material properties to precisely fit your requirements for a wide range of application areas, including cell therapies, drug delivery, and high-throughput screening.
If you require specific material design characteristics or assistance choosing the PeptiGel® that's most suitable for your application, please get in touch.

