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High versatility PODS®

Simple, effective reprogramming of phagocytic cells

Mononuclear phagocytic cells such as monocytes, macrophages and dendritic cells are at the vanguard of our immune system. Harnessing the capabilities of these cells has tremendous potential for fighting disease. 

Rather than reprogramming at the level of DNA or RNA, researchers are now using PODS® sustained-release proteins to efficiently reprogram the proteome directly. With 70% of cells reprogrammed in 24 hours, no expansion is needed.

Whether you are developing new therapies or simply delving into the mechanisms of the immune system, PODS® can help you with your quest. 

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Cell Guidance Systems Blog

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Are exosomes effective in cosmetics?

Are exosomes effective in cosmetics?

How robust is the evidence supporting the effectiveness of exosomes in costmetics? Where do these exosomes come from? And how large is the market for exosome-infused products?

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An easier way to model biological gradients

An easier way to model biological gradients

Protein gradients, especially of cytokines and chemokines, are essential in biology for guiding cell migration, activating immunity, and orchestrating development. Traditional methods often struggle with unstable delivery, burst release, or limited spatial control. Here, we review common approaches and highlight the befits of PODS as a powerful, next-generation tool for engineering reliable protein gradients.

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How to generate microRNA sequence data from EVs

How to generate microRNA sequence data from EVs

Isolating EVs in a form compatible with downstream next-generation sequencing (NGS), particularly for small RNA analysis, can be technically challenging. But using the right kits to process the samples, many different groups have now developed an efficient workflow that is generating valuable EV microRNA data.

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