Recombinant Mouse IP-10 / CXCL10 Protein
Interferon Inducible Protein 10 / CXCL10
Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto′s thyroiditis, Graves′disease and Type 1 diabetes mellitus.The chemokine IP-10 (interferon-inducible protein of 10 kDa, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells. Recombinant Mouse IP-10 is a single, non- glycosylated, polypeptide chain.
Mouse IP-10 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract IL-2 activated T cells at 0.1-10 ng/ml.
|77 αα||8.7 kDa||Q548V9
Sterile filtered white lyophilized (freeze-dried) powder.
Lyophilized with no additives.
Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Lyophilized product is very stable at -20°C. Reconstituted material should be aliquoted and frozen at -20°C. It is recommended to add a carrier protein (0.1% HSA or BSA) for long term storage.
Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug.
Protein Content determined by
UV spectroscopy at 280 nm. Analysis by RP-HPLC calibrated against a known standard. Quantitation on SDS-PAGE against a known standard.
chemokine (C-X-C motif) ligand 10, Small-inducible cytokine B10, IP-10,10 kDa, interferon gamma-induced protein, INP10, SCYB10, small inducible cytokine subfamily B (Cys-X-Cys) member 10, protein 10 from interferon (gamma)-induced cell line2, IFI101, C-X-C motif chemokine 10, crg-2, interferon-inducible cytokine IP-10, mob-1, gamma-IP10, gIP-10, gamma IP10, C7, Gamma-IP10
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RESEARCH USE ONLY