Standard proteins are extracted from cells using harsh processes that damage the protein, fail to remove impurities (which can have a biological effect) and leave the protein product unprotected from proteases. Although these proteins work instantly, they don't work for long. PODS™ proteins are captured within the cell in a polyhedrin crystal lattice which protects the protein against physical and chemical damage. Once deployed in cell culture, the polyhedrin crystal loosens its grip on the cargo protein providing a sustained release into the local environment. PODS™ crystals provide a depot formulation for sustained protein release over days, weeks and months (when combined with a hydrogel). PODS™ crystals can be attached to surfaces in order to functionalize them and thus create localized concentrations and physiologically relevant gradients.
Depot formulation provides sustained release and maintains physiologically relevant concentrations of growth factors over extended periods
Proteins remain folded throughout production process providing inherent biological activity
Manufactured in insect cells for important post-translational modifications
Animal Free manufacture
Custom service available. Difficult-to-purify proteins can be made