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Supporting your research

Life science researchers working across the globe, often working in small labs with limited resources, are striving to tackle the many challenges that the world faces. Whether addressing disease, hunger or environmental destruction, researchers like you are making a real difference.

At Cell Guidance Systems, we are supporting your efforts. We have developed a range of innovative products and services that make your research more effective by enhancing, simplifying and accelerating your workflow.

We provide our best to you. So you can give your best to the world. Together, we can make a difference.

Cell Guidance Systems Blog

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Pharmacokinetics: What is it and why is it important?

Pharmacokinetics:  What is it and why is it important?

For a drug to be successful, just as important as what the drug does to the body, is what the body does to the drug. Not only is it important to transport therapeutic drugs effectively to where they are needed, but once it is there, they have to remain long enough to have an effect. Studies to understand a drug's journey through the body are in the domain of drug metabolism and pharmacokinetics, usually abbreviated to DMPK.

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Thalidomide, the trailblazing molecular glue degrader

Thalidomide, the trailblazing molecular glue degrader

From 1957 to 1961, Thalidomide, a small molecule drug, was prescribed to treat a range of conditions in pregnant women including morning sickness. The developmental abnormalities that it caused in the developing foetus made the drug synonymous with pharmaceutical negligence. Despite this, in 1988, thalidomide was approved for the safe treatment of leprosy and cancer.

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Could FGF17 rejuvenate the brain?

Could FGF17 rejuvenate the brain?

Rapidly increasing public and private research funding is increasing our understanding of the ageing process. This is starting to yield results that could allow therapeutic intervention. Surprisingly, it seems a single cytokine could modulate brain ageing. Could we be on the verge of therapies that will extend the limits of human health?

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Zebrafish embryo surprised by morphogen cluster synergy

Zebrafish embryo surprised by morphogen cluster synergy

The development of complex multicellular forms, such as this zebrafish, relies on the activity of morphogen gradients acting differentially on individual cell surface receptors. The way receptors and their ligands present themselves to each other, either dispersed or in clusters, has a dramatic impact on the consequences of their interaction.

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Green fingers: Plant scaffolds for body parts

Green fingers: Plant scaffolds for body parts

Wood, bamboo and other plant-derived materials are widely used to provide structural integrity for buildings. It turns out that plant-derived scaffolds can also be used, on a much smaller scale, to support the culture of cells grown in 3D. Importantly, as well as providing structure, plant structures can provide vasculature, on a similar scale to our own, enabling nutrients and signalling molecules to be carried to cells that are distant from the surface.

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Cytokine storm in a teacup: Growth factor dynamics in cell culture

Cytokine storm in a teacup: Growth factor dynamics in cell culture

Recombinant cytokines and other growth factors underpin cell culture and are as important to biotechnology as semi-conductors are to information technology. They also provide a source of cell-based assay variability. Understanding cytokine dynamics is important to the design of better cell-based assays and manufacturing systems.

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Exosome dominoes: How acute pancreatitis leads to lung injury

Exosome dominoes: How acute pancreatitis leads to lung injury

Acute pancreatitis (AP) is a sudden and severe inflammation of the pancreas sometimes caused by gallstones. In the most severe cases, AP can also lead to injury of the lung. The pathway from pancreatic disease to lung injury is anything but direct and a fundamental role for exosomes has emerged.

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Cancer wars: the return of the cytokine

Cancer wars: the return of the cytokine

In the 1890s, William Coley (pictured) pioneered techniques that boost immune activity against cancer by injecting pathogens into cancer patients to stimulate their immune system. The modern emergence of onco-immunotherapy began with the therapeutic development of cytokines. These messenger proteins modulate both innate and adaptive immunity. Although they have been overshadowed by checkpoint inhibitors for the last decade, there is renewed interest in targeting and harnessing cytokines for cancer immunotherapy.

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