Mononuclear phagocytic cells such as monocytes, macrophages and dendritic cells are at the vanguard of our immune system. Harnessing the capabilities of these cells has tremendous potential for fighting disease.
Rather than reprogramming at the level of DNA or RNA, researchers are now using PODS® sustained-release proteins to efficiently reprogram the proteome directly. With 70% of cells reprogrammed in 24 hours, no expansion is needed.
Whether you are developing new therapies or simply delving into the mechanisms of the immune system, PODS® can help you with your quest.
Often overlooked, matrix stiffness is hugely important to the behaviour of cells. A recent study of prostate cancer cells using gels of varying stiffness reveals mechanistic insights.
Complex models of the bone marrow tissue, capable of replicating functional niches that maintain multipotent haemopoietic stem cells, are on the horizon. These models will enable more realistic and informative in-vitro studies of drugs for haematological diseases as well as assessing the myelotoxicty of treatments targeted at other tissues.
Cancer of the prostate, a small gland that produces seminal fluid in men, is one of the most common cancers and the 5th leading cause of male death worldwide. Men over the age of 50, those of African descent, or those with a family history of prostate cancer are at a higher risk. Additionally, diet, particularly diets high in fat and sugar, can increase the likelihood of prostate cancer by negatively affecting the gut microbiome.
Last week, two groups reported encouraging clinical trial results of iPSC-based autologous cellular therapy for Parkinsons disease (PD). However, the implanted cells' poor survival may have undermined these results.
Immunotherapy, boosting the activity of the immune system, is widely used in cancer treatment. Success has been achieved with a variety of modalities, including adoptive cellular immunotherapy, antibodies, tumour vaccines, and small-molecule inhibitors. Tumour-associated macrophages (TAMs) play a key role in treatment outcome for many of these modalities even if the treatment does not target them directly.
Using lasers, hydrogels and sustained release neurotropic growth factors, researchers in Switzerland have developed a sophisticated nerve conduit system to repair non-union nerve damage.
Cells communicate by their secretions, impacting the behaviour of other cells. Cell secretion therapies use living cells to produce and secrete therapeutic substances that can aid in treating diseases. These include extracellular vesicles (EVs), cytokines, chemokines and hormones. Such therapies are at the forefront of regenerative medicine and immunotherapy.
A deadly arms race takes place between cancer cells and our immune system. A recent study published in Nature shows the importance of monocytes in the development of a healthy anti-cancer immune response, how cancer blocks monocyte activity and how this can be restored.
