0 items$0.00

Accelerate towards your research goals

We provide reagents and services for cell-based research.

Our innovative printable PODS growth factors, conventional growth factors, and small molecules serve to guide and support cells. Our wide range of surfaces and extracellular matrix products, including Softwell and the versatile PeptiGel self-assembling peptide hydrogels (SAPHs) enable more challenging cell culture. Our highly-cited karyotyping service ensures the integrity of your cell-based work.

For extracellular vesicle research, Cell Guidance Systems products and services enable the purification and subsequent analysis of exosomes and other EVs.

 

Cell Guidance Systems Blog

See all blog articles

Polyhedrin microparticle neuronal drug delivery

Polyhedrin microparticle neuronal drug delivery

Drug delivery to the central nervous system (CNS) is challenging. CNS drugs, for example, that are unable to cross the blood-brain barrier (BBB) cannot be delivered orally or intravenously. Developing drug delivery technologies that can address the specific challenges of delivery to the CNS is a very active area of research. The interaction between drugs and immune cells modulates pharmacodynamics. A new paper from researchers at Keele University explores the interaction between a candidate drug microparticle technology and brain immune cells.

Read More

Freeze dried exosomes trialled to treat diabetic foot ulcers

Freeze dried exosomes trialled to treat diabetic foot ulcers

Extracellular vesicles (EVs), including exosomes, can be used therapeutically. Rion, a company spun out of the Mayo Clinic in Rochester, Minnesota, recently began phase II trials to evaluate the use of a powdered formulation of platelet-derived exosomes to treat diabetic foot ulcers.

Read More

PeptiGel vs Collagen

PeptiGel vs Collagen

When discussing 3D Cell Culture, researchers and scientists will talk about collagen, as it is quite popular as a matrix material. Collagen does have limitations as a scaffold though, in a similar way to many other natural scaffold materials, which is one of the reasons why Cell Guidance Systems are offering a fully synthetic alternative – PeptiGels.

Read More

3Rs: Tiny amounts of Matrigel sufficient for mammary epithelial cell organoids

3Rs: Tiny amounts of Matrigel sufficient for  mammary epithelial cell organoids

3Rs aims to reduce, refine and replace the use of animals in research. Matrigel and similar basement membrane extracts are widely used in cell culture as an extracellular scaffold support and also provide key matrix proteins. The sacrifice of mice to generate Matrigel is one of the biggest single uses of animals in research. A new method to culture mammary epithelial cell (MEC) organoids shows that Matrigel use can be dramatically reduced or even (at a cost) eliminated.

Read More

Bacteria in metastases: The microbiome of cancer

Bacteria in metastases: The microbiome of cancer

Within our bodies, microbes have developed an essential, commensal role and are found in many niches. A comprehensive study, recently published in Cell, provides a fascinating insight into the role of microbes in cancer and how they can modulate prognosis and responses to treatment.

Read More

Options for 3D Cell Culture: The Benefits of PeptiGel

Options for 3D Cell Culture: The Benefits of PeptiGel

3D cell culture has emerged as a pivotal technique for mimicking the natural environment of cells. This method offers a more physiologically relevant context compared to traditional 2D cultures, better enabling the study of cell behavior, drug responses, and disease mechanisms. In this article, we will delve into the pros and cons of various hydrogels used in 3D cell culture and highlight the unique benefits of using PeptiGel.

Read More

What are the biggest proteins?

What are the biggest proteins?

For proteins, size does matter. The size of proteins is related to their function. Most of the really big proteins are found in muscles. Muscle cells are specialized for contraction and force generation, processes that rely on the precise organization and interaction of several large protein complexes.

Read More

Newsletter