PeptiGel® Technology

PeptiGels® peptide hydrogels are fully synthetic and spontaneously self-assemble to form 3D nano-fibrous hydrogels that mimic the native extracellular matrix (ECM). The mechanical stiffness of these hydrogels is modulated and matches the stiffness of most tissue types. The fibre surfaces can be (bio)chemically functionalised with several biomimetic peptide sequences from key ECM proteins that are proven to signal and enhance biological processes. These include RGD (fibronectin), IKVAV (laminin), YIGSR (laminin) and GFOGER (collagen).

The ability to tune the properties of the peptide hydrogels to provide the optimal environment for your cells’ needs, makes them the ideal synthetic alternative to animal derived matrices such as Matrigel™, Geltrex™ and collagen.


As peptides are the building blocks of nature, PeptiGels® are inherently biocompatible and provide a suitable environment for cells to survive and thrive


Core technology benefits


PeptiGels® work - what researchers say



Webinar: How to Successfully Make the Switch to Synthetic Peptide Hydrogels 

 Professor Aline Miller (University of Manchester) and Sebastian Doherty-Boyd (University of Glasgow) discuss the difficulties in producing consistent cell culture results using traditional biomaterials, particularly animal-derived matrices with their inherent variability. They also discuss how to gain greater control over 2D and 3D cell culture with PeptiGels and cover specific examples of using PeptiGels to generate 3D tissue and disease models. Published: September 2023


Comparison of 2D cell culture and 3D cell culture with PeptiGel®

PeptiGels® can be used for 2D and 3D cell culture, and have been proven successful in supporting a range of application areas. See how they compare. 


2D vs. 3D cell culture

2D Cell Culture

3D Cell Culture

Not representative of the in-vivo environment Better simulation of the in-vivo environment
Altered cell-to-cell interactions and signalling Enhanced cell-to-cell interactions and signalling
Need for animal testing for validation Reduction in animal usage
Limited in its application areas Wide-ranging applications e.g. integration of fluid flow and bioprinting
Lack of in-vivo predictivity Reliable and relevant results
Simple to analyse Improved method to model diseases
Well established Not as widely explored


PeptiGels® are easy to handle