Cell Guidance Systems Blog

A clear vision for the future of curing retinal diseases

A clear vision for the future of curing retinal diseases

It is accepted wisdom that the visual sense is the dominant of the five senses for us humans. A notion that also has translated into sensory research. Or as the author of a paper in 2019 asked “Why Is There So Much More Research on Vision Than on Any Other Sensory Modality?” in which he observed that more textbook and journal article inches are spent on vision than on any other sensory modality across multiple disciplines ranging from biomedical sciences to perception and cognitive psychology.

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Exosomes for targeted doxorubicin chemotherapy

Exosomes for targeted doxorubicin chemotherapy

Chemotherapy, using chemicals that are particularly toxic to rapidly dividing cancer cells, is the most commonly used cancer treatment, often in combination with surgery and/or radiotherapy. However, the side effects of chemotherapy are severe. Exosomes may offer a way of better targeting chemotherapy to cancer cells.

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Exosomal-PD-L1 predicts treatment response in melanoma patients

Exosomal-PD-L1 predicts treatment response in melanoma patients

Many cancers have developed an efficient way of blocking the body’s natural immune response by overexpressing a protein called programmed death ligand-1 (PD-L1). Antibodies that neutralize PD-L1 are highly effective in some patients. Exosome-based diagnostics can predict responders.

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Exosome therapeutics in development for treating Covid

Exosome therapeutics in development for treating Covid

Times of crisis can precipitate rapid technological development and the Covid-19 crisis is presenting an opportunity for new therapeutic modalities. Pfizer/BioNTech and Moderna’s Covid vaccines which both rely on RNA have been ground-breaking. Could Covid-19 also clear the path for the first exosome therapeutics?

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Diseases in a dish: Challenges of iPSC-based disease modelling

Diseases in a dish: Challenges of iPSC-based disease modelling

Despite iPSCs having potential in many biomedical applications, there are currently major challenges that need to be addressed to unleash the full potential of iPSCs for disease modelling, both in clinical settings and their use for safety pharmacology to provide more effective and safer regenerative therapy.

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PODS prepare macrophages to treat disease

PODS prepare macrophages to treat disease

Cell Guidance Systems Ltd, a specialist in the control, manipulation and monitoring of cells, both in vitro and in vivo, today announced its POlyhedrin Delivery System (PODS) technology has been shown to modulate macrophage secretion profiles with therapeutic potential. The results of this research are available as an unpublished preprint in bioRxiv1.

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Cells, gels and wells: the rise of 3D bioprinting

Cells, gels and wells: the rise of 3D bioprinting

The growth of 3D cell printing over the last decade has been remarkable with 41% compound annual growth. In this mini-report, we look at key players with offerings targeted at the burgeoning 3D cell bioprinting market.

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