Cell Guidance Systems Blog

How 3D bioprinters are advancing cancer research

How 3D bioprinters are advancing cancer research

Cancer is the second leading cause of death worldwide, after cardiovascular disease, with over 16.4 million cancer-related deaths predicted by 2040. It is well known for its complex and dynamic nature, which has meant that it is challenging to study with 2D cell culture models, although understanding of the disease has improved.

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Meet us at ISSCR in Hamburg

Meet us at ISSCR in Hamburg

We're attending ISSCR in Hamburg from 10-12 July Come and say hello and find out about our products and services. We're going to be featuring PODS, the 100% protein slow-release growth factors

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Improving cell therapy by in situ development

Improving cell therapy by in situ development

In autologous cell therapy, cells that originate in the patient are returned to the patient for therapeutic purposes. If we accept the obvious notion that human cells grow best in humans, the quicker cells can be re-implanted, the better. But many cells require complex, sustained manipulation to differentiate and mature into the cells required for therapeutic effect. Technologies that enable cells to differentiate and maturate autonomously in the patient following implant will enable this goal.

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Growth factor kinetics in vivo and in vitro

Growth factor kinetics in vivo and in vitro

It is important to understand that there is a big difference between in vivo and in vitro stability of growth factors. In-vivo, growth factor half-lives can be just a few minutes. But the same growth factors have in-vitro half-lives of a few hours. What causes this?

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Printing better celluarized blood vessels with PODS

Printing better celluarized blood vessels with PODS

In an exciting development, biomaterials scientists have used advanced biomaterials and an ingenious manufacturing method to produce co-axial extruded, cellularized blood vessels incorporating cells derived in situ from fat stem cells from the patient.

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Pseudotime vs. actual time for genes

Pseudotime vs. actual time for genes

As well as actual, canonical time marked by ticking of a clock, time can be marked by events. Pseudotime and canonical expression time are concepts used in the study of gene expression dynamics, particularly in the context of developmental biology and single-cell RNA sequencing (scRNA-seq).

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Are some cell types more receptive to exosomes?

Are some cell types more receptive to exosomes?

The ability of cells to generate exosomes varies significantly between different types of cells. Cancer cells, for example, reliably yield large amounts of exosomes when grown in culture. Immune cells and MSCs are also relatively high-yielding. But what about exosome ingestion?

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Polyhedrin microparticle neuronal drug delivery

Polyhedrin microparticle neuronal drug delivery

Drug delivery to the central nervous system (CNS) is challenging. CNS drugs, for example, that are unable to cross the blood-brain barrier (BBB) cannot be delivered orally or intravenously. Developing drug delivery technologies that can address the specific challenges of delivery to the CNS is a very active area of research. The interaction between drugs and immune cells modulates pharmacodynamics. A new paper from researchers at Keele University explores the interaction between a candidate drug microparticle technology and brain immune cells.

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