It is important to understand that there is a big difference between in vivo and in vitro stability of growth factors. In-vivo, growth factor half-lives can be just a few minutes. But the same growth factors have in-vitro half-lives of a few hours. What causes this?
In an exciting development, biomaterials scientists have used advanced biomaterials and an ingenious manufacturing method to produce co-axial extruded, cellularized blood vessels incorporating cells derived in situ from fat stem cells from the patient.
As well as actual, canonical time marked by ticking of a clock, time can be marked by events. Pseudotime and canonical expression time are concepts used in the study of gene expression dynamics, particularly in the context of developmental biology and single-cell RNA sequencing (scRNA-seq).
The ability of cells to generate exosomes varies significantly between different types of cells. Cancer cells, for example, reliably yield large amounts of exosomes when grown in culture. Immune cells and MSCs are also relatively high-yielding. But what about exosome ingestion?
