Viral vectors, such as AAV, are used for the delivery of RNA and DNA therapeutics. Machine learning is enabling the rapid iterative development and improvement of these therapeutic vectors.
Pressure regulation, valves, and balanced distribution: A domestic heating system and the human circulatory system share a remarkably wide range of similarities.
Karyotyping remains an important assay when working with any animal cell. Here we discuss the benefits and limitations.
Tropical climates yield high levels of biodiversity. So perhaps it is not surprising that the natural resources of many tropical islands have made significant contributions to the development of some very big (and some not so big) name drugs.
The genomic instability of iPSCs is well documented. What is the impact of these genetic alterations on downstream applications and what can we do to mitigate their impact?
Scientific fraud, while not extremely common, is a significant concern within the scientific community. Does the lack of reproducibility point to a greater problem?
Within our bodies, microbes have developed an essential, commensal role and are found in many niches. A comprehensive study, recently published in Cell, provides a fascinating insight into the role of microbes in cancer and how they can modulate prognosis and responses to treatment.
For proteins, size does matter. The size of proteins is related to their function. Most of the really big proteins are found in muscles. Muscle cells are specialized for contraction and force generation, processes that rely on the precise organization and interaction of several large protein complexes.
Over the last 25 years, the survival statistics for cancer patients have improved. Changes in lifestyle (e.g. smoking), earlier detection and better therapies have all contributed. Here, we look at which cancers have the best, worst and most improved survival rates.
Understanding the way a drug interacts with our body, and the risks that this poses, is a critical part of drug development. In this article, we describe the basic aspects of ADME Tox, with specific examples.
