Molecular structure such as small molecules and proteins are typically measure in Daltons. Whereas larger structures are measure in grams. We thought it would be interesting to apply both scales across a range of biological entities, from a water molecule to blue whale.
Last week, a Nobel prize was awarded for the discovery of T-Reg cells. When and how many immune cells have been identified and are there likely more lurking in the shadows?
Rising sea levels, extreme weather, and ecosystem disruption, are well known consequences of climate change, but emerging research also reveals a more intimate threat: climate change may be directly damaging our chromosomes and altering our genetic makeup. This hidden consequence could have profound implications for human health and evolution.
Biological research standards are the invisible agreements that make life science actually scientific. Creating these standards is more complicated (and political) than most people realize.
Artificial Intelligence (AI) is revolutionizing industries across the globe, and one of its most impactful applications is in the biomedical field.
Defining a set of secreted proteins that are associated with morbidities and conditions in later life is helping to develop treatments to increase healthspan and lifespan
We explore the status of CAR T-cell therapy in the treatment of solid tumors, possible causes of failure, potential solutions, and the progress of CAR T-cell therapy for solid tumors and discuss the possible significance of CAR T-cell therapy for cancer treatment in the future.
CAR-T has been revolutionary, but as an autologous therapy, it is slow and costly. Allogeneic CAR-T cells, known as iNKTS, are now in development and may offer a rapid, cheaper (and perhaps more effective) off-the-shelf solution.
Targeted protein degradation (TPD) is an emerging technique used to study cellular processes and develop new therapies. Introduced in 1999, TPD works by breaking down specific proteins using either the proteasomal or lysosomal pathways. Most current TPD methods, such as PROTACs, molecular glues, Trim-Away, and SNIPERs, depend on the ubiquitin-proteasome system (UPS) and are primarily designed to target proteins inside cells.
When presented with cancer cells, our cytogeneticists often see tiny chromosomal structures known as double minutes. What are these, how are they formed, and what is their importance?
