March 2024

To reduce the required frequency of drug administration, technologies have been developed to offer prolonged therapeutic effects, minimizing systemic side effects. These technologies are particularly useful for chronic conditions, localized diseases, and situations where continuous protein delivery is beneficial. Technologies that have been developed for sustained, localized release include:

There has been an increasing move towards the use of 3D cell culture as a means of functional differentiation in recent years. Although 2D cell cultures have been useful in a lot of ways, research has shown that they can differ significantly from in vivo conditions making it difficult to replicate the findings in a clinical setting. This, along with the failure rate and relatively high cost of drug development, has meant there is now an urgent need to find more predictive research models across all fields.

Understanding the way a drug interacts with our body, and the risks that this poses, is a critical part of drug development. In this article, we describe the basic aspects of ADME Tox, with specific examples.

Cell Guidance Systems today launches our primary liver-derived microsome products. These new products join our growing range of primary cell products launched last year.