How polyhedrin functions as a viral survival strategy, and how the PODS (Polyhedrin Delivery System) mechanism harnesses polyhedrin's crystalline architecture to encapsulate growth factors and control their release over days to weeks.
For decades, researchers have been searching for a reliable, clinically translatable way around this formidable BBB obstacle. Researchers in China may now have found one.
Researchers are turning to PODS sustained release chemokines to readily generate stable chemokine gradients in vitro and in vivo without any specialist equipment.
Providing building blocks for controlled protein release, the inspired use of PODS is enabling research breakthroughs across biomedical science.
Poor survival of implanted retinal cells has held back therapeutic development. Sustained neurotrophic growth factor release is pushing the field forwards
Sustained release PODS-TGF-B2 enabled powerful modelling of trabecular meshwork,
Growth factors are critical controllers of cell behaviour. By providing printability and sustained release, PODS are increasing our ability to harness these key molecules in cell culture and cell therapy
Protein gradients, especially of cytokines and chemokines, are essential in biology for guiding cell migration, activating immunity, and orchestrating development. Traditional methods often struggle with unstable delivery, burst release, or limited spatial control. Here, we review common approaches and highlight the befits of PODS as a powerful, next-generation tool for engineering reliable protein gradients.
Researchers in Tokyo have leveraged PODS protein crystals to create a gold-harvesting technology that is environmentally friendly and more selective than most synthetic materials.
A new study led by researchers at the University of Glasgow presents compelling evidence of PODS ability to elevate organoid-based therapies to a new level.
