Cell Guidance Systems Blog

3D cell culture has emerged as a pivotal technique for mimicking the natural environment of cells. This method offers a more physiologically relevant context compared to traditional 2D cultures, better enabling the study of cell behavior, drug responses, and disease mechanisms. In this article, we will delve into the pros and cons of various hydrogels used in 3D cell culture and highlight the unique benefits of using PeptiGel.

For proteins, size does matter. The size of proteins is related to their function. Most of the really big proteins are found in muscles. Muscle cells are specialized for contraction and force generation, processes that rely on the precise organization and interaction of several large protein complexes.

Over the last 25 years, the survival statistics for cancer patients have improved. Changes in lifestyle (e.g. smoking), earlier detection and better therapies have all contributed. Here, we look at which cancers have the best, worst and most improved survival rates.

To reduce the required frequency of drug administration, technologies have been developed to offer prolonged therapeutic effects, minimizing systemic side effects. These technologies are particularly useful for chronic conditions, localized diseases, and situations where continuous protein delivery is beneficial. Technologies that have been developed for sustained, localized release include:

There has been an increasing move towards the use of 3D cell culture as a means of functional differentiation in recent years. Although 2D cell cultures have been useful in a lot of ways, research has shown that they can differ significantly from in vivo conditions making it difficult to replicate the findings in a clinical setting. This, along with the failure rate and relatively high cost of drug development, has meant there is now an urgent need to find more predictive research models across all fields.

Understanding the way a drug interacts with our body, and the risks that this poses, is a critical part of drug development. In this article, we describe the basic aspects of ADME Tox, with specific examples.

Cell Guidance Systems today launches our primary liver-derived microsome products. These new products join our growing range of primary cell products launched last year.

The delivery of protein drugs to metastatic tumors is fraught with obstacles that limit their efficacy. This article explores the barriers to the delivery of protein drugs to metastatic cancer and discusses strategies to overcome these challenges.

Scaffolds have an important role to play in tissue engineering, as they are a substrate that can be used to mimic the native extracellular matrix (ECM). The properties of scaffolds have also been shown to affect cell behaviour such as cell attachment, differentiation and proliferation.

These versatile cells, known for their multiple roles in engulfing and digesting cellular debris, pathogens, and attacking cancer cells as well as rebuilding damaged tissue, are at the center of a new wave of treatments. Companies around the world are exploiting the unique properties of macrophages to develop groundbreaking therapies for a wide range of diseases.