Cell Guidance Systems Blog

Diseases in a dish: Challenges of iPSC-based disease modelling

Diseases in a dish: Challenges of iPSC-based disease modelling

Despite iPSCs having potential in many biomedical applications, there are currently major challenges that need to be addressed to unleash the full potential of iPSCs for disease modelling, both in clinical settings and their use for safety pharmacology to provide more effective and safer regenerative therapy.

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PODS prepare macrophages to treat disease

PODS prepare macrophages to treat disease

Cell Guidance Systems Ltd, a specialist in the control, manipulation and monitoring of cells, both in vitro and in vivo, today announced its POlyhedrin Delivery System (PODS) technology has been shown to modulate macrophage secretion profiles with therapeutic potential. The results of this research are available as an unpublished preprint in bioRxiv1.

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Cells, gels and wells: the rise of 3D bioprinting

Cells, gels and wells: the rise of 3D bioprinting

The growth of 3D cell printing over the last decade has been remarkable with 41% compound annual growth. In this mini-report, we look at key players with offerings targeted at the burgeoning 3D cell bioprinting market.

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Input materials for cultured meat

Input materials for cultured meat

What if we could reliably build cell-based structures resembling meat step-by-step in a lab, bypassing the need for livestock altogether? Advances in cellular biology, including identifying the signals that cause stem cells to turn into other cell types such as muscle or fat cells, have given us the key to unlock this possibility, with many companies founded in recent years to develop this technology.

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Schrödinger's cytokine

Schrödinger's cytokine

Resident cytokines (released from cells in the body) are potent proteins that function at vanishingly low levels (measured in ng/kg). In contrast, therapeutic recombinant cytokines are typically dosed in mg/kg. Similarly, high mg/L concentrations are required for cytokines used in lab-based cell culture or in biomanufacturing. How do almost non-existent resident cytokines manage to achieve their effects?

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A lot on the plate: high-throughput exosome isolation

A lot on the plate: high-throughput exosome isolation

Size exclusion chromatography (SEC) is fast becoming the purification method of choice for extracellular vesicles including exosomes. However, the technique has been confined to relatively low throughput, single-column formats. Continued improvementsas led to a new high-throughput isolation product that has overcome this limitation.

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Understanding and reducing variability in cell-based assays.

Understanding and reducing variability in cell-based assays.

Cell-based assays are a cornerstone of research and drug development. However, the beneficial effects of promising drugs can easily be missed amidst the noise of experimental data. This means good drug candidates are often overlooked. Just as concerning, data that would otherwise flag problematic candidates can be missed allowing drug candidates to progress to later stages before eventually failing.

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Refining 3D Cell Culture Systems for Drug Discovery

Refining 3D Cell Culture Systems for Drug Discovery

Three-dimensional (3D) culture systems are becoming increasingly popular in both biomedical research and in drug discovery. It is becoming widely accepted that in vitro 3D cell culture technologies have the ability to mimic tissue-like structures and both physiological and disease states more effectively than traditional two-dimensional (2D) monolayer cultures on plastic surfaces.

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Organoids increasingly used to model pancreatic cancer

Organoids increasingly used to model pancreatic cancer

Despite recent remarkable advances in the treatment of some cancers, pancreatic cancer patients still have one of the worst survival rates. Pancreatic ductal adenocarcinoma’s (PDAC) five-year survival is only 2%-9%. This poor prognosis can largely be attributed to two major factors. Firstly, owing to relatively benign presenting features, the disease is not diagnosed until it has progressed to advanced or metastatic stages in >70% of patients.

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We'll meat again: diets are becoming more cultured

We'll meat again: diets are becoming more cultured

Vegetarianism and veganism have become increasingly popular over the last few years, with the number of vegans increasing. In the UK for example, veganism has increased from 150,000 in 2014 to 600,000 in 2019. This is equivalent to about 0.8% of the population. Ten countries have rates of vegetarianism above 10%. The most common reasons people chose to undertake a dietary change relate to both the environmental impact of animal agriculture and, of course, animal welfare. With this in mind, could lab=grown meat provide a more ethical way for people to include meat products in their diet?

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