Exosomes and viruses have many things in common, including their size, lipid coat, and the ability to transport RNA and proteins between cells. Exosomes and viruses co-purify using techniques including size exclusion chromatography. Are these similarities a coincidence or is there a shared past?
Neutrophils and macrophages are key players in the early immune response to infection. In a recent paper, published in Science Advances, a team of researchers at Vanderbilt University have further explored neutrophil NETosis, a process whereby neutrophils initially secrete, and ultimately autolyse, to generate a sticky mesh which immobilizes the pathogen. The researchers have shown that this mesh actively enables and empowers the subsequent activity of macrophages.
Fetal maturation rate and birth timing are both regulated by factors including hormones, nutrients, and adipokines. Increasingly, the contribution of exosomes to the establishment of a successful pregnancy and delivery process is becoming clear. Exosomes regulate the physiology and metabolism of both the mother and the fetus by acting as messengers that carry specific biological signals between cells/tissuesâ€”generating an intimate relationship between them.
The long-term effects of disease and injury can arise from the body's efforts to regenerate damaged tissue. Scarring of the skin is one example. Internal scarring of tissue can also occur which can lead to more than superficial effects. In Covid 19 and other airway infections, pulmonary fibrosis, driven by cytokines, can have serious implications.