2D Primary human hepatocyte cultures can suffer from rapid dedifferentiation and loss of liver-specific functions. The advent of three-dimensional (3D) cell culture technologies, such as hepatocyte spheroids offered by Cell Guidance Systems has revolutionized the field.
The extracellular matrix (ECM) is a vital component for the growth and function of any cell. It typically contains a mix of fibrous and non-fibrous proteins such as collagen, laminin and fibronectin, proteoglycans, growth factors and signalling molecules that provide both structural and biochemical support for cells.
Cancer treatment has long been a battlefield of precision, targeting tumors with treatments like surgery, chemotherapy, and radiation. However, a rare and fascinating phenomenon known as the abscopal effect has intrigued oncologists and researchers, offering a glimpse into the hidden power of the body to fight cancer beyond the direct line of treatment.
Increasing antibiotic resistance amongst pathogens is alarming. Self-assembling peptides (SAPHs) such as PeptiGel are a class of peptides that can spontaneously organize into well-defined structures, such as fibres, gels, or nanoparticles, under certain conditions. When designed to have antimicrobial properties, these peptides can offer several benefits and face various challenges when used as anti-microbial peptides (AMPs).
The extracellular matrix (ECM) is one of the major structural components of the tumour microenvironment, as it is made up of a network of biochemically different components such as fibrous proteins, glycoproteins, proteoglycans and polysaccharides. This makes its structure highly dynamic with various ECM components being deposited, modified or degraded on a regular basis, and the structure undergoing constant remodelling.
