Karyotype Analysis
The leading and reliable service for karyotype analysis
Please follow the instructions for preparing live and fixed shipments, respectively. Include the following statements on the Customs Invoice: "The packed material is classified as 'not restricted'. The material will be used for laboratory research only. The material contains no pharmaceutical properties."
What is karyotyping?
Karyotype analysis is a cytogenetic test that enables the identification of numerical and structural chromosomal abnormalities. Using conventional Giemsa staining techniques, condensed chromosomes are G-banded for observation. Chromosomes are subsequently grouped according to their size, centromere position and banding pattern, and any potential aberrations are identified.
Why karyotyping is important
Karyotyping is the gold standard test required by scientific journals and regulatory agencies to assess the genetic integrity of cells. It is also critical as a regular quality control step to ensure that cells being worked with have not become abnormal. Any abnormality may give rise to altered metabolic and differentiation pathways. Retrospectively discovering that cells are abnormal can invalidate months or years of research. Karyotyping can be used to detect low-level mosaicism and balanced translocations which are easily missed by other methods. Learn more from our webinar.
Webinar: Karyotyping iPSCs for chromosomal abnormalities
Seven reasons to choose Cell Guidance Systems karyotype service
- Clinically qualified cytogeneticists with >30 years combined experience
- GMP-compliant quality management system
- Adherence to peer-reviewed methods
- Open to customer audit
- Flexible to customer's specific requirements
- Reliable, highly cited service
- Express option available
Request a quote
Use Karyotype analysis to detect:
Service format
Clinical samples for diagnostic purposes are not accepted.
Common species:
- Human
- Mouse
We also have capabilities for
- Cow karyotyping (bovine karyotyping)
- Pig karyotyping (porcine karyotyping)
- Sheep karyotyping (ovine karyotyping)
- Goat karyotyping (caprine karyotyping)
- Chicken karyotyping (gallus karyotyping)
- Dog karyotyping (canine karyotyping)
- Horse karyotyping (equine karyotyping)
Contact us for further details or if your species isn't listed.
Service levels
We accept 2 types of samples in our laboratories:
- Live cells: cells arrive in culture in a T25 flask (available for UK and Europe only)
- Fixed cells: cells arrive fixed in a 2 mL screwcap tube - we will provide detailed instructions on how to prepare the cells
Please do not send any samples without booking in advance
Number of cells analyzed:
- Normal cells: 20 cells are analyzed per sample as a minimum. This number can be increased to your requirements
- For unstable cancer/highly abnormal samples: sufficient cells will be characterized to identify clonal abnormalities
Reporting times:
- Standard service: 7-10 business days (human or mouse)*
- An Express service is available: please contact us to check availability and turnaround before ordering
*Please note that reporting times may be longer during peak periods. This guidance is for human and mouse. Other species may take longer. You will be advised of any expected delays when placing an order.
Report format
The service results include a descriptive report and at least one publication-quality image of a representative karyotype.
Example Normal Human female from iPS cells
Biosafety level
We can process BSL1 as fixed or live cell samples. We can only process BSL2 samples received as fixed cells.
Protocols and workflow
If you have any questions, please contact us by email at [email protected]. We will respond within one business day.