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Life Sciences Innovator 2023

Supporting your research

Life science researchers are working to address urgent global challenges. From rare diseases to pandemics, hunger and environmental destruction, your research is contributing to our shared future.

At Cell Guidance Systems, we are focussed on supporting your efforts. We provide a range of innovative products and services that make your research more effective by enhancing, simplifying and accelerating experimental workflow.

We provide our best to you. So you can give your best to the world. Together, we are making a difference.

Cell Guidance Systems Blog

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Cytokines and Organ Rejection

Cytokines and Organ Rejection

Organ transplantation is a life-saving procedure for patients with end-stage organ failure. However, one of the major challenges in transplantation is the immune-mediated rejection of the transplanted organ by the recipient's immune system. Cytokines, a group of small proteins secreted by immune cells, play a crucial role in the immune response and are involved in the process of organ rejection.

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Hydrogels for 3D Bioprinting

Hydrogels for 3D Bioprinting

Three-dimensional (3D) bioprinting is an emerging technology that enables the fabrication of complex, biomimetic tissue constructs for applications in tissue engineering, regenerative medicine, and drug testing. Hydrogels, which are hydrophilic polymeric networks capable of absorbing large amounts of water, have emerged as promising bioinks for 3D bioprinting due to their biocompatibility, tunable mechanical properties, and ability to support cell adhesion, proliferation, and differentiation.

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Better delivering cytokines for cancer therapy

Better delivering cytokines for cancer therapy

In 2013, the journal Science chose cancer immunotherapy as the breakthrough of the year, largely due to the impact of checkpoint inhibitors. Interleukin-2 (IL-2), a cytokine, also played a part. In addition to IL-2, interferon-gamma (IFN-g), and interleukin-12 (IL-12) have come to prominence in recent years. However, toxicity limits their use. Can this be overcome?

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Drug-induced liver injury

Drug-induced liver injury

The liver is the largest vital organ responsible for functions including metabolism, immunity, digestion, detoxification and endocrine regulation. Its multifaceted role, unique anatomical features and specialized blood supply - receiving blood directly from the GI tract and heart - render it an indispensable target for therapeutic interventions aimed at addressing liver diseases and improving overall health outcomes.

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Inflammaging: How our cytokines age us

Inflammaging: How our cytokines age us

Inflammation is a natural biological response to tissue injury or infection, but chronic low-grade inflammation, also known as inflammaging, is a hallmark of ageing. In recent years, the relationship between cytokines, inflammation, and ageing has become established.

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Nanoparticle and microparticle drug delivery to the liver

Nanoparticle and microparticle drug delivery to the liver

Liver disease is a significant health concern that affects millions of people worldwide. The liver plays a crucial role in metabolism, detoxification, and bile production, and liver disease can significantly impact liver function. Early diagnosis and treatment are essential for managing liver disease, and nanoparticles and microparticles offer promising therapeutic approaches for early-stage liver disease.

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Charlie and the cytokine factory

Charlie and the cytokine factory

Chocolate directly affects immune system performance. Stripping back the confounding effects of other components, such as sugar, cocoa itself promotes beneficial changes which are reflected in levels of pro- and anti-inflammatory cytokines.

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