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Growth factor quality, versatility, choice

We are the only company that provides both conventional growth factors as well as formulated PODS® depot sustained-release growth factors. 

Why is formulation important? Growth factors are released by cells in a constant stream at just the right level to support cellular function. Tissue development and homeostasis rely on this. 

PODS® mimic this process by providing a constant stream of growth factors to support your cells. Learn more here

 

 

 

Cell Guidance Systems Blog

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How do growth factors cause cell differentiation?

How do growth factors cause cell differentiation?

As well as causing the proliferation of cells, growth factors can promote differentiation and even the death of cells. For example, the differentiation of neuronal progenitor cells to functional neuronal cells is regulated by so-called neurotrophic growth factors. As with the proliferative growth factors, neurotrophic growth factors initiate a complex cascade of events by binding to receptor proteins that span the cell surface:

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How do growth factors cause cell division?

How do growth factors cause cell division?

Growth factors are crucial proteins in regulating various cellular processes, including differentiation and cell division. Simulation of cell division is triggered when particular growth factors bind cell receptors. This triggers a cascade of events through a series of steps that result in mitosis and cell division.

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Normoxia: Are we cramping cell culture?

Normoxia: Are we cramping cell culture?

During strenuous exercise, anaerobic conditions develop in our muscles as cells rapidly use oxygen. Muscle cells switch to an alternative metabolic pathway that releases lactic acid to cope with reduced oxygen levels. When lactic acid builds up, it can cause cramps. Similarly, media depth can dramatically impact oxygen levels in cell culture. Standardizing this variable, or agitation may help to improve data reproducibility and relevance in cell culture.

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The more the better: not always for growth factors

The more the better: not always for growth factors

Most growth factors produce a sigmoidal dose response curve. However, biphasic responses can also be generated, even from a single receptor. The specific reasons underlying a biphasic dose response caused by FGF-2 biding to FGFR1 have been elucidated.

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Aptamer-exosomes as sensors in Alzheimer disease models

Aptamer-exosomes as sensors in Alzheimer disease models

Aptamers, from the Latin word aptus, meaning to fit, are short (20-100 nucleotide) sequences of synthetic DNA, RNA or peptides that can be used for binding to specific target molecules with high sensitivity and biocompatibility. Exosomes have been used to deliver ATP-sensing DNA aptamers in a model of Alzheimer disease.

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Catabolism vs anabolism: how growth factors govern key processes

Catabolism vs anabolism: how growth factors govern key processes

Metabolism in multicellular organisms is a complex interplay of biochemical processes that can be broadly categorized into two types: catabolism and anabolism. These processes, that are essential for maintaining life, enabling growth, and ensuring the proper functioning of cells and tissues, are controlled by growth factors and hormones.

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Toxic effects of overdosing growth factors in cell culture

Toxic effects of overdosing growth factors in cell culture

Growth factors are critical to many aspects of cell culture including proliferation, differentiation and maintenance. Whilst the effects of insufficient growth factor, such as lack of proliferation, are readily apparent, the effects of adding too much growth factor can be less apparent but equally important.

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