More EVs. Less effort. Lower cost.
The EVlution™ TFF System delivers high-yield, high-purity EV purification from up to 3 litres of starting material - in just 90 minutes. Unlike ultracentrifugation, EVlution™ is affordable, easy to use, and requires minimal hands-on time, freeing you to focus on what matters most: your research.
Its innovative Switch Flow™ technology reduces retentate volume to under 10 mL, maximising recovery while minimising loss. The compact, modular design supports 12 interchangeable polyethersulfone hollow fibre cartridge sizes, including the widely used 300 kDa and 500 kDa options optimised for EV concentration. Filters are reusable up to 20 times, keeping running costs low. EVlution™ pairs seamlessly with Exo-spin™ purification columns for a complete, end-to-end EV workflow.
Whether you're concentrating EVs, depleting FBS-associated particles, or performing buffer exchange, EVlution™ has you covered.
By analysing tumour-derived material circulating in blood, urine, or other body fluids, liquid biopsies offer a minimally invasive window into cancer biology in real time. Among the various analytes being explored, including circulating tumour cells (CTCs) and cell-free DNA (cfDNA), extracellular vesicles (EVs) are emerging as particularly compelling biomarker candidates.
A landmark study defines the protein and lipid signatures that distinguish authentic small extracellular vesicles in human plasma.
How TFF works, filter formats compared, and why EVlution belongs on your bench
EVlution, a new affordable bench top Tangential Flow Filtration (TFF) system launches today. It makes scalable, reproducible extracellular vesicle purification accessible to more laboratories, accelerating innovation in EV research and translational development.
Embryo implantation is a tightly timed conversation between embryo and endometrium; one that has to coordinate adhesion, immune tolerance, tissue remodelling, and blood-vessel changes within a narrow window of implantation. A major set of words in that conversation are extracellular vesicles (EVs), including exosomes; nano-sized packages released by cells that carry proteins, lipids, and nucleic acids (like miRNAs) to influence recipient cells.
Among all adult human tissues, the brain occupies the extreme low end of the mechanical stiffness spectrum. While the body contains structures engineered for load bearing, tension, and compression, the brain is optimized for signalling, plasticity, and metabolic exchange. Its mechanical softness is not incidental. It is fundamental to its biological function.
In cell biology, immunology, and drug development, cytokines and growth factors are rarely discussed purely in terms of mass. Instead, their potency is often expressed in International Units (IU) a convention that can confuse even experienced researchers. Why are some cytokines defined in IU, others sold only by weight, and why do IU values seem to vary between suppliers?
Studies reported in Science and Nature Materials using Softwell highlight the importance of softness in cell behaviour. The study of cell signalling has traditionally focused on chemical cues such as growth factors, cytokines, transcriptional regulators and, more recently, extracellular vesicles (EVs) as the primary drivers of cell behaviour. Yet cells do not exist in isolation. Every cell resides in a physical environment that pushes, pulls, resists and deforms it. Increasingly, research is showing that this physical context is not secondary, but fundamental.
