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We provide reagents and services for cell-based research.

Our innovative printable PODS growth factors, conventional growth factors, and small molecules serve to guide and support cells. Our wide range of surfaces and extracellular matrix products, including Softwell and the versatile PeptiGel self-assembling peptide hydrogels (SAPHs) enable more challenging cell culture. Our highly-cited karyotyping service ensures the integrity of your cell-based work.

For extracellular vesicle research, Cell Guidance Systems products and services enable the purification and subsequent analysis of exosomes and other EVs.

Click to learn how PODS are being developed to treat cancer

Cell Guidance Systems Blog

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What are the biggest proteins?

What are the biggest proteins?

For proteins, size does matter. The size of proteins is related to their function. Most of the really big proteins are found in muscles. Muscle cells are specialized for contraction and force generation, processes that rely on the precise organization and interaction of several large protein complexes.

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Cancers with the best, worst and most improved prognosis

Cancers with the best, worst and most improved prognosis

Over the last 25 years, the survival statistics for cancer patients have improved. Changes in lifestyle (e.g. smoking), earlier detection and better therapies have all contributed. Here, we look at which cancers have the best, worst and most improved survival rates.

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Local, longer: Sustained drug release

Local, longer: Sustained drug release

To reduce the required frequency of drug administration, technologies have been developed to offer prolonged therapeutic effects, minimizing systemic side effects. These technologies are particularly useful for chronic conditions, localized diseases, and situations where continuous protein delivery is beneficial. Technologies that have been developed for sustained, localized release include:

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Organoids for disease modelling

Organoids for disease modelling

There has been an increasing move towards the use of 3D cell culture as a means of functional differentiation in recent years. Although 2D cell cultures have been useful in a lot of ways, research has shown that they can differ significantly from in vivo conditions making it difficult to replicate the findings in a clinical setting. This, along with the failure rate and relatively high cost of drug development, has meant there is now an urgent need to find more predictive research models across all fields.

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A beginners guide to ADME Tox

A beginners guide to ADME Tox

Understanding the way a drug interacts with our body, and the risks that this poses, is a critical part of drug development. In this article, we describe the basic aspects of ADME Tox, with specific examples.

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Overcoming barriers to cancer protein drug delivery

Overcoming barriers to cancer protein drug delivery

The delivery of protein drugs to metastatic tumors is fraught with obstacles that limit their efficacy. This article explores the barriers to the delivery of protein drugs to metastatic cancer and discusses strategies to overcome these challenges.

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The Right Stiff: scaffolds for 3D cell culture

The Right Stiff: scaffolds for 3D cell culture

Scaffolds have an important role to play in tissue engineering, as they are a substrate that can be used to mimic the native extracellular matrix (ECM). The properties of scaffolds have also been shown to affect cell behaviour such as cell attachment, differentiation and proliferation.

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