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Accelerate towards your research goals

We provide reagents and services for cell-based research.

Our innovative printable PODS growth factors, conventional growth factors, and small molecules serve to guide and support cells. Our wide range of surfaces and extracellular matrix products, including Softwell and the versatile PeptiGel self-assembling peptide hydrogels (SAPHs) enable more challenging cell culture. Our highly-cited karyotyping service ensures the integrity of your cell-based work.

For extracellular vesicle research, Cell Guidance Systems products and services enable the purification and subsequent analysis of exosomes and other EVs.

We're here to support your research.

Cell Guidance Systems Blog

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Overcoming barriers to cancer protein drug delivery

Overcoming barriers to cancer protein drug delivery

The delivery of protein drugs to metastatic tumors is fraught with obstacles that limit their efficacy. This article explores the barriers to the delivery of protein drugs to metastatic cancer and discusses strategies to overcome these challenges.

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The Right Stiff: scaffolds for 3D cell culture

The Right Stiff: scaffolds for 3D cell culture

Scaffolds have an important role to play in tissue engineering, as they are a substrate that can be used to mimic the native extracellular matrix (ECM). The properties of scaffolds have also been shown to affect cell behaviour such as cell attachment, differentiation and proliferation.

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Harnessing Macrophages to treat disease

Harnessing Macrophages to treat disease

These versatile cells, known for their multiple roles in engulfing and digesting cellular debris, pathogens, and attacking cancer cells as well as rebuilding damaged tissue, are at the center of a new wave of treatments. Companies around the world are exploiting the unique properties of macrophages to develop groundbreaking therapies for a wide range of diseases.

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Harnessing Phagocytic Immune Cells to Breach Cancer Fortifications

Harnessing Phagocytic Immune Cells to Breach Cancer Fortifications

One of the most significant hurdles in combating metastatic cancer is the delivery of protein drugs to the affected sites. The cancer cells fortify themselves behind endothelial barriers and extracellular matrix, making it difficult for therapeutic agents to reach and destroy them. Employing phagocytic immune cells as Trojan horses to overcome these barriers has immense potential.

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Functionalized hydrogels: better in vivo mimicry

Functionalized hydrogels: better in vivo mimicry

The extracellular matrix (ECM) is a vital component for the growth and function of any cell. It typically contains a mix of fibrous and non-fibrous proteins such as collagen, laminin and fibronectin, proteoglycans, growth factors and signalling molecules that provide both structural and biochemical support for cells.

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The abscopal effect: unexpected cancer therapeutic dividends

The abscopal effect: unexpected cancer therapeutic dividends

Cancer treatment has long been a battlefield of precision, targeting tumors with treatments like surgery, chemotherapy, and radiation. However, a rare and fascinating phenomenon known as the abscopal effect has intrigued oncologists and researchers, offering a glimpse into the hidden power of the body to fight cancer beyond the direct line of treatment.

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Advantages and challenges of SAPHs as anti-microbials

Advantages and challenges of SAPHs as anti-microbials

Increasing antibiotic resistance amongst pathogens is alarming. Self-assembling peptides (SAPHs) such as PeptiGel are a class of peptides that can spontaneously organize into well-defined structures, such as fibres, gels, or nanoparticles, under certain conditions. When designed to have antimicrobial properties, these peptides can offer several benefits and face various challenges when used as anti-microbial peptides (AMPs).

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