A study reported this week demonstrates a novel approach to delivering protein drugs to joints to repair cartilage defects. This may lead to the development of the first effective drug for osteoarthritis that will be able to delay or possibly remove the need for joint replacement surgery.
Dr Shu discusses his recent review paper "Co-Isolation of Cytokines and Exosomes: Implications for Immunomodulation Studies". Exosomes play a vital role in intercellular communication and their immunomodulatory potential has become an important focus in cancer research. In melanoma, tumor-derived exosomes drive immunosuppression within the tumor microenvironment.
Cell Guidance Systems Ltd, a specialist in the control, manipulation and monitoring of cells, both in vitro and in vivo, today announced its POlyhedrin Delivery System (PODS) technology has been shown to modulate macrophage secretion profiles with therapeutic potential. The results of this research are available as an unpublished preprint in bioRxiv1.
Size exclusion chromatography (SEC) is fast becoming the purification method of choice for extracellular vesicles including exosomes. However, the technique has been confined to relatively low throughput, single-column formats. Continued improvementsas led to a new high-throughput isolation product that has overcome this limitation.
This year's UK annual extracellular vesicle meeting is being held virtually and CellGS will be presenting its latest offering for exosome research, the Exo-spinâ„¢ 96 kit.
Cell Guidance Systems Ltd, a specialist in exosome research reagents and services, today announced the launch of a new product for the purification of exosomes from blood and other samples. The Exo-spinâ„¢ 96 exosome purification kit allows researchers to purify exosome samples in the standard 96 well plate format.
Growth factors (GFs), which include cytokines, are rather unstable proteins with half-lives sometimes as short as a few minutes. This instability is an important part of their function. Imagine GFs that persisted for months in-vivo: they would be widely diffused and their ability to define tissues would be lost.
Exo-spinâ„¢ SEC columns can be used as a stand-alone product or as part of a combined strategy for isolating small EVs. CellGS offers pre-packed and equilibrated ready-to-use SEC columns. With the pore size of the resin being approximately 30 nm, Exo-spinâ„¢ SEC columns offer a highly pure exosome elution ready for any downstream application.
We are thrilled to announce the launch of a new kit for exosome isolation!
