The calorie-rich environment of the modern world is leading to poorer diets for many people. Excess calories contribute to inflammation throughout the body, early-onset of age-related diseases/mortality and a shorter life expectancy. Extreme calorie restriction, 50% below recommended daily limits, may increase lifespan beyond current levels. However, for many people, this is not a price worth paying. Can drugs allow us to achieve greater longevity without severe calorie restriction?
Cell Guidance Systems Blog
Diseases that primarily affect the brain, often resulting in dementia, are some of the most prevalent, devastating, and yet poorly treated of all diseases. Despite advances in our knowledge of basic neurosciences, the failure rate for new drugs targeting important central nervous system (CNS) diseases still exceeds most other areas of drug discovery. A significant barrier to drug development for these diseases is presented by the blood-brain barrier (BBB).
Ultracentrifugation is often described as the â€œgold standardâ€ to isolate or purify extracellular vesicles (EVs) including exosomes. Now, a collaborative EV study led by researchers at Clemson University in South Carolina, has shown that for purification of EVs from urine samples, this gold standard can be improved with a simple modification.
In addition to substrate elasticity (durotaxis) and chemical gradients (chemotaxis), which we explored in previous blog articles, surface topography also impacts cell movement and behavior. Cells develop and function embedded within in a highly complexâ€”and evolvingâ€”extracellular matrix (ECM) environment. Various biochemical and biophysical ECM cellular cues and their subsequent cell responses shape the development and homeostasis of tissues. An important component of this extracellular environment, governing cell function and behaviour, is the differing micro-/nanotopographical features.
In a previous article about durotaxis, we discussed how cell movements can be guided by elasticity cues at the cell-substrate interface. Here, we focus on the process of cell migration following biochemical cues and the clinical benefits promised by this developing area of research.
A study reported this week demonstrates a novel approach to delivering protein drugs to joints to repair cartilage defects. This may lead to the development of the first effective drug for osteoarthritis that will be able to delay or possibly remove the need for joint replacement surgery.
The distinction between peptides and proteins is not always apparent, but it is important to understand. Peptides and proteins are, indeed, fundamentally the same, each being composed of amino acids held together by peptide bonds. However, fundamental differences between proteins and peptides go beyond an arbitrary length threshold. Look closer and they differ in structure, function, and therapeutic use.
Since as early as the 1990s, a myriad of AI-driven healthcare technology has successfully reached the market. Perhaps one of most astoundingâ€”and maybe slightly unsettlingâ€”inventions of all involves the development of Xenobots, a new class of synthetic organisms that blur the lines between the physical, digital and biological worlds.
A recent paper exploring the use of optimized virus like particles (VLPs) to deliver base editing proteins has shown impressive levels of efficacy and, importantly, low levels of off-target activity in mouse models of therapy for brain, eye and liver disease.
In this report, we provide details on 45 companies that have emerged over the last decade to pursue exosome therapeutics and diagnostic goals. Two tables provide a quick reference for this information on investor funding and founding date. A further table provides a summary of 242 exosome-focused clinical trials.