Cell Guidance Systems Blog

Plant vs. Animal Extracellular Vesicles (EVs)

Plant vs. Animal Extracellular Vesicles (EVs)

EVs are best known in the context of mammalian systems, where exosomes and microvesicles play critical roles in intercellular communication. However, plants also release vesicle-like particles with intriguing parallels, and key differences, from their animal counterparts.

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Can Natural Killer EVs treat cancer?

Can Natural Killer EVs treat cancer?

Natural killer (NK) cells are part of the innate immune system and can identify and destroy cancer cells without prior sensitization to specific targets. These lymphocytes act as the body's first line of defense, using specialized receptors to distinguish between healthy and abnormal cells.

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Are exosomes effective in cosmetics?

Are exosomes effective in cosmetics?

How robust is the evidence supporting the effectiveness of exosomes in costmetics? Where do these exosomes come from? And how large is the market for exosome-infused products?

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An easier way to model biological gradients

An easier way to model biological gradients

Protein gradients, especially of cytokines and chemokines, are essential in biology for guiding cell migration, activating immunity, and orchestrating development. Traditional methods often struggle with unstable delivery, burst release, or limited spatial control. Here, we review common approaches and highlight the befits of PODS as a powerful, next-generation tool for engineering reliable protein gradients.

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How to generate microRNA sequence data from EVs

How to generate microRNA sequence data from EVs

Isolating EVs in a form compatible with downstream next-generation sequencing (NGS), particularly for small RNA analysis, can be technically challenging. But using the right kits to process the samples, many different groups have now developed an efficient workflow that is generating valuable EV microRNA data.

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