Cell Guidance Systems Blog

Exosomes' emerging potential to diagnose and treat rheumatoid arthritis

Exosomes' emerging potential to diagnose and treat rheumatoid arthritis

The role of exosomes in the development of autoimmune diseases is increasingly well understood. Amongst these, rheumatoid arthritis is one of the most common. It affects about 1% of women and 0.5% of men in OECD nations. Over the last decade, the potential use of exosomes for the treatment of rheumatoid arthritis has become a hot topic.

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Diverse approaches emerge for exosome therapy to treat Covid-19

Diverse approaches emerge for exosome therapy to treat Covid-19

An unprecedented effort led to the rapid development of vaccines and therapeutics to mitigate the impact of Covid 19. Vaccines against SARS-CoV-2 are highly effective in limiting the incidence of severe disease. But with new variants emerging and patchy vaccination coverage, large numbers of people are still becoming severely affected and dying.

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A chemokine biomarker for assessing your immune age

A chemokine biomarker for assessing your immune age

Why do some people age faster than others? A recent study has allowed the development of an inflammation index to determine a person’s “immunological age”. This index may be useful in healthcare assessments, and may also allow early-stage interventions, such as improved diet and exercise.

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Exosomes in autoimmune disease

Exosomes in autoimmune disease

A pathogenic role of microRNAs (miRNAs) derived from exosomes has been attributed to a growing list of autoimmune conditions. Using exosomes as a biomarker to diagnose autoimmune conditions could help healthcare providers offer effective care prior to irreversible damage.

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Biological gradients

Biological gradients

Biological gradients, including ion, oxygen, and protein concentration, are constantly forming and dissipating within cells and tissues. Gradients created by the secretion or metabolism of morphogens enable complex patterning. Without these gradients, complex organisms could not develop.

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Platelet-derived exosomes can help heal ischemic skin wounds

Platelet-derived exosomes can help heal ischemic skin wounds

Inadequate blood supply to the skin can promote the development of wounds. These so-called ischemic wounds affect millions of people and can lead to amputations or even loss of life. Researchers at the Mayo Clinic recently reported their studies in which they examined the use of exosomes containing TGF-β to treat chronic skin wounds.

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Orally delivered microbial exosomes induce anti-tumor immunity

Orally delivered microbial exosomes induce anti-tumor immunity

The therapeutic effects of transplanted stem cells can be mediated by their exosomes. Since exosomes offer relative simplicity and are tolerated without the need for immunosuppressive drugs, there is increasing interest in using exosomes for therapy rather than cells. There may be advantages to using exosomes from microorganisms therapeutically too.

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Does too little phagocytosis lead to autism?

Does too little phagocytosis lead to autism?

Tissue remodeling and homeostasis are the processes that modulate and maintain the size and shape of tissues. Phagocytosis plays an important role in these processes. A recent publication in PNAS provides evidence that a mutation that reduces the efficiency of phagocytosis may lead to abnormalities in brain development that are associated with enlarged brains seen in some instances of autism.

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Shipping update for EU customers

“Changes are being made to customs procedures for goods shipped from the UK to the EU. From 1st July, VAT will be charged to EU customers at the point of entry at the standard rate of VAT in the buyer's country of residence. FedEx will collect the VAT and charge a €12 admin fee. The customer is responsible for these charges. For business customers, it will be possible to reclaim the VAT paid.

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