Cell Guidance Systems Blog

Are exosomes effective in cosmetics?

Are exosomes effective in cosmetics?

How robust is the evidence supporting the effectiveness of exosomes in costmetics? Where do these exosomes come from? And how large is the market for exosome-infused products?

Read More

An easier way to model biological gradients

An easier way to model biological gradients

Protein gradients, especially of cytokines and chemokines, are essential in biology for guiding cell migration, activating immunity, and orchestrating development. Traditional methods often struggle with unstable delivery, burst release, or limited spatial control. Here, we review common approaches and highlight the befits of PODS as a powerful, next-generation tool for engineering reliable protein gradients.

Read More

How to generate microRNA sequence data from EVs

How to generate microRNA sequence data from EVs

Isolating EVs in a form compatible with downstream next-generation sequencing (NGS), particularly for small RNA analysis, can be technically challenging. But using the right kits to process the samples, many different groups have now developed an efficient workflow that is generating valuable EV microRNA data.

Read More

Can CAR-T cells succeed in solid cancers?

Can CAR-T cells succeed in solid cancers?

We explore the status of CAR T-cell therapy in the treatment of solid tumors, possible causes of failure, potential solutions, and the progress of CAR T-cell therapy for solid tumors and discuss the possible significance of CAR T-cell therapy for cancer treatment in the future.

Read More

iNKing out cancer: A better CAR-T cell?

iNKing out cancer: A better CAR-T cell?

CAR-T has been revolutionary, but as an autologous therapy, it is slow and costly. Allogeneic CAR-T cells, known as iNKTS, are now in development and may offer a rapid, cheaper (and perhaps more effective) off-the-shelf solution.

Read More