Cell Guidance Systems Blog

Just why do growth factors have such short half-lives?

Just why do growth factors have such short half-lives?

Anyone working in stem cell culture is painfully aware of the short half-lives of growth factors. These very expensive little proteins rapidly degrade which means time and money spent replacing them. But the ephemeral nature of growth factors is critical to their functionality

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Towards synthetic alternatives to Matrigel for regenerative medicine applications.

Towards synthetic alternatives to Matrigel for regenerative medicine applications.

Matrigel and similar products such as Geltrex, have become essential reagents for 3D cell culture. Matrigel contains a mixture of major basement-membrane extracellular matrix (ECM) proteins (e.g. laminin, collagen IV, entactin and the heparin sulphate proteoglycan perlecan). It is also packed with growth factors and many enzymes. As such, it provides an ideal structural and biological environment for culturing cells and is used in a myriad of applications in many formats.

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Biological applications of HEMA hydrogels

Biological applications of HEMA hydrogels

Hydrogels are defined as a 3-dimensional network capable of absorbing water without becoming solvated - a property they share with most soft tissues within the body. This similarity has led to rising levels of research focussed on using hydrogels in the field of tissue engineering and regeneration as analogues for ECM and assisting wound healing, as well as extensive use in contact lens production both for vision corrective as well as therapeutic treatments

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Trojan Horses in therapeutics- half way through the city gate

Trojan Horses in therapeutics- half way through the city gate

In drug development, the term Trojan horse encompasses a variety of strategies to deliver drugs in a concealed, safe and efficient way to the target. The main objectives of this strategy are firstly to overcome barriers, such as the blood brain-barrier or simply the cell membrane, which shield the target (Troy) from a drug (the Greeks), secondly, to specifically attack the disease rather than the whole body and thirdly, to achieve a slow drug release over time with no sudden concentration peaks. This approach does not only sound awesome on a metaphoric level, but also makes use of some nifty biological tricks.

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Plant Derived Exosomes: Potential therapeutic delivery systems?

Plant Derived Exosomes: Potential therapeutic delivery systems?

Exosomes are cell-secreted vesicles with a diameter between 30-150nm which contain producer cell-derived protein, lipid and nucleic acid cargoes. Exosomes complex structure, coated with various membrane-bound proteins, can permeate target cells, enabling direct cell-to-cell communication between neighbouring and distant cells. Now researchers are looking at the possibility of using exosomes derived from plants for therapeutic applications

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The importance of exosome characterization

The importance of exosome characterization

The characterisation of exosomes via multiple, complimentary techniques is necessary as a basic step to understand the sample before any further analysis. Here we discuss how products and services from Cell Guidance Systems can help with this important task.

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Exosomes in cancer management

Exosomes in cancer management

Exosomes play an important role in both local and systemic cellular communication, carrying most types of biomolecules (including DNAs, RNAs, proteins and lipids) between cells and tissues. The properties of exosomes may allow us to utilize them for therapeutic and clinical purposes. Cancer management is an attractive target.

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Anti-bacterial exosomes from bee products

Anti-bacterial exosomes from bee products

A recent study published by collaborators working in Chile is the first to describe some remarkable anti-bacterial properties of exosome-like vesicles (ELVs) isolated from honeybee products including honey, royal jelly and pollen

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