PeptiGel® Alpha 2™

Code Description Price Qty
PA2-5 PeptiGel® Alpha 2™, 5 ml $395.00
PA2-20 PeptiGel® Alpha 2™, 20 ml $1,390.00
PA2-50 PeptiGel® Alpha 2™, 50 ml $2,990.00
PA2-SP PeptiGel® Alpha 2™ Starter Pack $1,095.00
PeptiGel® Alpha 2™

Synthetic Self-Assembling Peptide Hydrogels

PeptiGels® are ready-to-use fully synthetic peptide hydrogels that are biologically relevant and formulated to meet your cells’ needs. PeptiGels® are used for 2D and 3D cell culture and are specifically designed with a range of mechanical properties and chemical functionalities to mimic the native cellular micro-environment to allow the growth of any cell type.

Product Description

PeptiGel® Alpha 2™ is a ready-to-use fully synthetic positively charged peptide hydrogel. PeptiGel® Alpha 2™ is biologically relevant, mimics the extracellular matrix and is suitable for the culture of a variety of cells, including neuronal cells.

PeptiGel® Alpha 2™ is a stiffer hydrogel when compared to Alpha 4 but has consistent mechanical stiffness (G’) and pore size, resulting in excellent reproducible results. PeptiGel® Alpha 2™ can be used for both in-vitro and in-vivo applications with physiologically and clinically relevant results.

Value Starter Pack

When beginning to work with PeptiGels®, we recommend purchasing our Value Starter Pack. This includes PeptiGel® to test with your cells to enable you to identify the most suitable matrix environment. The Pack also includes a Gilson positive displacement pipette (various sizes are available), a box of sterile tips and a pack of Greiner Thincerts. Contact us for additional information.

Case Studies

PeptiGel® outperforms Matrigel™

PeptiGel Alpha 2 vs. Matrigel

 

PeptiGel® Alpha 2™ supports quicker growth of fully formed gastro-intestinal organoids than Matrigel™. 

 

Tailored PeptiGel® properties mimic the mechanical and chemical environment of healthy and cancer tissue

                 

Tumour mimicking (stiff and acidic) PeptiGel® Alpha 2™ results in increased proliferation of Pancreatic Ductal Adenocarcinoma suit-2 cells. 

 

PeptiGel® enables the migration of resident cells into injury 

                 

PeptiGel® Alpha 2™ implanted in the brain was well tolerated and supported the migration of resident cells into a lesion created by treatment with collagenase. 

References

  • Lachowski D, Matellan C, Cortes E, Saiani A, Miller AF and del Río Hernández AE. (2021) Self-assembling polypeptide hydrogels as a platform to recapitulate the tumor microenvironment. Cancers 13(13): 3286.
  • King K, Cartwright E, Oceandy D, Zi M, Facchi C and Njegic A. (2022) BS43 Pro-angiogenic injectable self-assembling peptide hydrogel as a delivery vehicle for cardiac cell therapies. Heart 108, A171-A172.
  • Clough HC, O'Brien M, Zhu X, Miller AF, Saiani A and Tsigkou O. (2021) Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression. Materials Science and Engineering 127: 112200
Product Details
Formulation

Synthetic, self-assembling peptide hydrogel

Charge

Positive (+1)

pH

3.8 - 4.2

Mechanical Properties (kPa)

6.0 - 8.0

Biocompatibility

Non-toxic, safe for animal studies  

Biodegradability

Biodegradable, supports cell activities

Functional motif: GFOGER (Collagen)

No

Functional motif: RGD (Fibronectin)

No

Stability and Storage

At least 6 months when stored at 4°C as supplied.

Shipping Temperature

Ambient