PeptiGel® Alpha 4 PLUS™
Demonstrated Compatible Cells
Stromal Fibroblasts | Ovary A2780 | Colon Crypts
Synthetic Self-Assembling Peptide Hydrogels
PeptiGels® are ready-to-use fully synthetic self-assembling peptide hydrogels that are biologically relevant and formulated to meet your cells’ needs. PeptiGels® are used for 2D and 3D cell culture and are specifically designed with a range of mechanical properties and chemical functionalities to mimic the native cellular micro-environment to allow the growth of any cell type.
Product Description
PeptiGel® Alpha 4 PLUS™ is a ready-to-use fully synthetic positively charged peptide hydrogel functionalized with fibronectin (RGD) and collagen (GFOGER) motifs, mimicking the extracellular matrix more closely and encouraging better cellular adhesion.
PeptiGel® Alpha 4 PLUS™ is suitable for the culture of a wide variety of cells, including primary cells, immortalized cells and stem cells, by offering enhanced cellular adhesion and cell-ECM signaling.
PeptiGel® Alpha 4 PLUS™ is a highly consistent hydrogel in mechanical stiffness (G’) and pore size, resulting in excellent reproducible results for both in-vitro and in-vivo applications.
Trial Size and Value Starter Pack
When beginning to work with PeptiGels®, we recommend purchasing our 1 ml trial pack sizes for new users. This allows you to evaluate the benefits of PeptiGel and PeptiInk hydrogels in your culture system at a very low cost. New users can purchase up to five 1 ml pack sizes.
We also offer a Value Starter Pack. This includes five versions of PeptiGel® of your choice (1 ml each) to test with your cells to enable you to identify the most suitable matrix environment. The Pack also includes a Gilson positive displacement pipette (various sizes are available), a box of sterile tips and a pack of Greiner Thincerts. Contact us for additional information.
References
- Clough HC, O'Brien M, Zhu X, Miller AF, Saiani A, and Tsigkou O. (2021) Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression. Materials Science and Engineering 127: 112200.
- King K, Njegic, A, Facchi, C, Prehar, S, Oceandy, D, Saiani, A and Cartwright, E. (2022) Development of a pro-angiogenic injectable self-assembling biomaterial for the delivery of induced pluripotent stem cell derived cardiomyocytes to the heart. Journal of Molecular and Cellular Cardiology 173, p.181.
- Gupta, P, Miller, A, Olayanju, A, Madhuri, TK and Velliou, E. (2022) A systematic comparative assessment of the response of ovarian cancer cells to the chemotherapeutic cisplatin in 3D models of various structural and biochemical configurations—does one model type fit all?. Cancers 14(5), p.1274.
| Product Details | |
|---|---|
| Formulation |
Synthetic, self-assembling peptide hydrogel |
| Charge |
Positive (+2) |
| pH |
6.2 - 7.2 |
| Mechanical Properties (kPa) |
0.7 - 1.3 |
| Biocompatibility |
Non-toxic, safe for animal studies |
| Biodegradability |
Biodegradable, supports cell activities |
| Functional motif: GFOGER (Collagen) |
Yes |
| Functional motif: RGD (Fibronectin) |
Yes |
| Stability and Storage |
At least 6 months from receipt when stored at 4°C as supplied |
| Shipping Temperature |
Ambient |
