PeptiGel® Alpha 1™
Demonstrated Compatible Cells
Chondrocytes | Monocytes | Nucleus Pulpous Cell | Schwann Cells | Oesophageal | Breast EpH4 | Fibroblast 3T3 | Kidney HEK293 | iPSCs
Synthetic Self-Assembling Peptide Hydrogels
PeptiGels® are ready-to-use fully synthetic self-assembling peptide hydrogels that are biologically relevant and formulated to meet your cells’ needs. PeptiGels® are used for 2D and 3D cell culture and are specifically designed with a range of mechanical properties and chemical functionalities to mimic the native cellular micro-environment to allow the growth of any cell type.
Product Description
PeptiGel® Alpha 1™ is a ready-to-use fully synthetic neutrally charged self-assembling peptide hydrogel. PeptiGel® Alpha 1™ is biologically relevant, mimics the extracellular matrix and is suitable for the culture of a variety of cells, including chondrocytes, nucleus pulposus cells and suspension cells.
PeptiGel® Alpha 1™ is a stiffer hydrogel when compared to Alpha 4™ but has consistent mechanical stiffness (G’) and pore size, resulting in excellent reproducible results. PeptiGel® Alpha 1™ can be used for both in-vitro and in-vivo applications with physiologically and clinically relevant results.
Value Starter Pack
When beginning to work with PeptiGels®, we recommend purchasing our Value Starter Pack. This includes PeptiGel® to test with your cells to enable you to identify the most suitable matrix environment. The Pack also includes a Gilson positive displacement pipette (various sizes are available), a box of sterile tips and a pack of Greiner Thincerts. Contact us for additional information.
Case Studies
PeptiGel® supports the formation of 3D breast cancer tumour models
PeptiGel® Alpha1™ supports a viable population of MCF-7 cells that are able to form spheroid structures.
PeptiGel® outperforms collagen
PeptiGel® Alpha1™ supports MCF-7 spheroids that are significantly larger and contain more cells than spheroids in Type 1 collagen.
References
- Clough HC, O'Brien M, Zhu X, Miller AF, Saiani A, Tsigkou O. (2021) Neutrally charged self-assembling peptide hydrogel recapitulates in vitro mechanisms of breast cancer progression. Materials Science and Engineering 127: 112200
| Product Details | |
|---|---|
| Formulation |
Synthetic, self-assembling peptide hydrogel |
| Charge |
Neutral |
| pH |
3.8 - 4.2 |
| Mechanical Properties (kPa) |
3.0 - 5.0 |
| Biocompatability |
Non-toxic, safe for animal studies |
| Biodegradability |
Biodegradable, supports cell activities |
| Functional motif: GFOGER (Collagen) |
No |
| Functional motif: RGD (Fibronectin) |
No |
| Stability and Storage |
At least 6 months from receipt when stored at 4°C as supplied. |
| Shipping Temperature |
Ambient |
