Non-parenchymal Cells, Human-derived

Product Description

Human-derived non-parenchymal cells for hepatocyte co-culture. 

Note: Samples are available for evaluation with the first order. The minimum order for this product is 10 vials. Please ask for a quote for >100 vials.

Hepatocytes alone are not able to fully represent in vivo functionality during toxicology evaluations. Co-cultures are a liver-derived in vitro model system that aims to preserve liver-specific morphology and functionality beyond what is provided by pure parenchymal cell cultures. 

Co-cultures can be prepared using hepatocytes and non-parenchymal cell (NPC) cultures which, has been evidenced to be one of the most successful models for maintaining functionality in vitro when examining drug related hepatotoxicity. NPCs can be co-cultured with hepatocytes in a basement membrane extract (BME) overlay. 

Suitable for a variety of assays including:

• DMPK evaluations
• Toxicology assessments