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PODS Growth Factors

The way proteins are delivered is critical to their function. PODS® provides stability and sustained release, addressing the limitations of conventional cytokines. PODS® are printable, localizable, sustained delivery growth factors. This allows control and manipulation of cells in 2D and 3D culture, as well as in-vivo.

 

What are PODS®?

  • Sub-micron scale co-crystals made 100% from protein
  • Contain a defined amount of a bioactive cargo protein plus a bio-inert scaffold protein
  • Antioxideant and Super-Dry (with only 19% solvent content) providing unparalleled stability
  • Slowly release their bioactive growth factor cargo through nanopores, generating steady-state bioavailability (near zero-order kinetics).
  • Pack sizes range from 5 µg to 1mg of the bioactive cargo protein

What are PODS® used for?

  • Reprogramming phagocytic cells, including monocytes and macrophages.
  • Functionalizing biomaterials
  • Localized sustained release in vitro and in vivo
  • Generating concentration gradients
  • Reducing the frequency of intervention in cell culture
  • Reducing temporal concentration variability

  

 

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