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In-vivo reprogramming of phagocytic cells

Mononuclear phagocytic cells such as monocytes, macrophages and dendritic cells are at the vanguard of our immune system. Harnessing the capabilities of these cells has tremendous potential for fighting disease. 

Rather than reprogramming at the level of DNA or RNA, researchers are now using PODS® sustained-release proteins to efficiently reprogram the proteome directly in-vivo. 

Whether you are developing new therapies or simply delving into the mechanisms of the immune system, PODS® can help you with your quest. 

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Cell Guidance Systems Blog

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Cancer Immunotherapy Models: The Right Scaffold Matters

Cancer Immunotherapy Models: The Right Scaffold Matters

Critical gaps between experimental models and clinical reality are the reason why clinical trials of promising drugs often fail. Closing those gaps can save huge amounts of money lost to failed trials. The right scaffold is critical to model accuracy

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PeptiGel: Revealing a Link Between Tumor Stiffness and Immune Suppression

PeptiGel: Revealing a Link Between Tumor Stiffness and Immune Suppression

When researchers at the University of Helsinki set out to understand how the mechanical properties of breast tumors affect immune cell behavior, they needed a culture system that could faithfully recreate different tissue environments. Their choice of PeptiGel as a 3D culture matrix proved instrumental in uncovering a surprising mechanism of immune suppression in breast cancer.

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Why do we use Daltons for protein mass?

Why do we use Daltons for protein mass?

Molecular structure such as small molecules and proteins are typically measure in Daltons. Whereas larger structures are measure in grams. Here we explain why, and how these units they relate to each other.

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