PODS Growth Factors
The way a bioactive protein, such as a cytokine, is delivered to its target is critical to function. PODS® are micron-scale protein depots that provide protein stability and sustained release, addressing the limitations of conventional cytokines. PODS® are printable, localizable, sustained delivery growth factors. This allows control and manipulation of cells in 2D and 3D culture, as well as in-vivo.
What are PODS®?
- Sub-micron scale co-crystals made 100% from protein
- Contain a defined amount of a bioactive cargo protein plus a bio-inert scaffold protein
- Antioxideant and Super-Dry (with only 19% solvent content) providing unparalleled stability
- Slowly release their bioactive growth factor cargo through nanopores, generating steady-state bioavailability (near zero-order kinetics).
- Pack sizes range from 5 µg to 1mg of the bioactive cargo protein
What are PODS® used for?
- Reprogramming phagocytic cells, including monocytes and macrophages.
- Functionalizing biomaterials
- Localized sustained release in vitro and in vivo
- Generating concentration gradients
- Reducing the frequency of intervention in cell culture
- Reducing temporal concentration variability