Recombinant Human β-defensin 3
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Descriptionβ-defensin 3 is a member of the defensin class of antimicrobial peptides. β-defensins exert host defense responses against viruses, bacteria, and fungi through the binding and permeabilizing of microbial membranes. β-defensin 3 expression is stimulated by IFN-γ and is an important molecule during adaptive immunity. β-defensin 3 functions to activate monocytes and mast cells, and has antibacterial functions towards Gram-negative and Gram-positive bacteria.
Activity AssayActivity to be determined.
AA SequenceGIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
Alternative NamesBDF-3, BD-3
|Molecular Weight||5.2 kDa|
|Purity||≥95% determined by reducing and non-reducing SDS-PAGE|
|Endotoxin Level||≤1.00 EU/μg as measured by kinetic LAL|
|Formulation||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)|
|Reconstitution||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM acetic acid at 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Stability and Storage||
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.