Recombinant Human β-defensin 3
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human β-defensin 3 has a predicted Mw of 5.2 kDa.
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PODS® Growth Factors
The product is currently not available as PODS®, please check back in the future.Description
β-defensin 3 is a member of the defensin class of antimicrobial peptides. β-defensins exert host defense responses against viruses, bacteria, and fungi through the binding and permeabilizing of microbial membranes. β-defensin 3 expression is stimulated by IFN-γ and is an important molecule during adaptive immunity. β-defensin 3 functions to activate monocytes and mast cells, and has antibacterial functions towards Gram-negative and Gram-positive bacteria.Activity Assay
Activity to be determined.AA Sequence
GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKKAlternative Names
BDF-3, BD-3| Product Details | |
|---|---|
| Length | 45 aa |
| Molecular Weight | 5.2 kDa |
| Structure | Monomer |
| Source | E. coli |
| Accession Number | P81534 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Reconstitution | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM acetic acid at 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Stability and Storage |
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. |
