CHIR99021
Summary
Purchase high quality CHIR99021 from a long-established and trusted source.
Activity
Cell Guidance Systems' CHIR99021 is a highly selective GSK-3β inhibitor (IC50 = 6.7 nM) widely used in stem cell research and iPSC reprogramming protocols. Our research-grade CHIR99021 delivers consistent, reproducible results with >99% purity and rigorous batch-to-batch quality control. The smallest vial includes our Exact Amount™ specification for precise experimental reproducibility. CHIR99021 is essential for WNT pathway activation in definitive endoderm differentiation and has been cited in over 1,000 peer-reviewed publications for iPSC generation and maintenance.
Effect
CHIR99021 is widely used in definitive endoderm differentiation protocols.
Alternative Names
CHIR-99021, CHIR 99021, CT 99021, CHIR 911, GSK-3 Inhibitor XVI
6-​[[2-​[[4-​(2,​4-​dichlorophenyl)-​5-​(5-​methyl-​1H-​imidazol-​2-​yl)-​2-​pyrimidinyl]amino]ethyl]amino]-​3-​pyridinecarbonitrile
References
1. Naujok, O., et al. 2014. BMC Res Notes. 7(1): 273. PMID: 24779365
2. Tsukiyama, T. and Ohinata, Y. 2014. PLoS One. 9(4): e95329. PMID: 24736627
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.
| Product Details | |
|---|---|
| Formula | C22H18Cl2N8 |
| Molecular Weight | 465.35 |
| CAS Number | 252917-06-9 |
| Purity | >99% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
