CHIR99021
CHIR99021
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
CHIR99021 is an aminopyrimidine derivative. CHIR99021 inhibits GSK3 beta (IC50 = 6.7 nM) and GSK3 alpha (IC50 = 10 nM) and functions as a WNT pathway activator.
Effect
CHIR99021 is widely used in definitive endoderm differentiation protocols.
Alternative Names
CHIR-99021, CHIR 99021, CT 99021, CHIR 911, GSK-3 Inhibitor XVI
6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
References
1. Naujok, O., et al. 2014. BMC Res Notes. 7(1): 273. PMID: 24779365
2. Tsukiyama, T. and Ohinata, Y. 2014. PLoS One. 9(4): e95329. PMID: 24736627
| Product Details | |
|---|---|
| Formula | C22H18Cl2N8 |
| Molecular Weight | 465.35 |
| CAS Number | 252917-06-9 |
| Purity | >99% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
