LY294002 shows a highly selective inhibitor of PI3K in-vivo. LY294002 can transfer cells to specific inhibition of PI3K, inhibition of PI3K/Akt signaling pathways, including inhibition of common Akt phosphorylation.
LY294002 inhibits cell proliferation of choroidal melanoma OCM-1 cells. In mouse embryonic stem cells, LY294002 prevents self-renewal by inhibiting LIF2.
LY 294002, LY-294002
1. Gharbi, SI., et al. 2007. Biochem J. 404(1): 15-21. PMID: 17302559