DAPT

Code Description Price Qty
SM15-2 DAPT, 2 mg £30.00
SM15-10 DAPT, 10 mg £85.00
SM15-50 DAPT, 50 mg £400.00
DAPT

Exact Amount™

The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.

Activity

DAPT is a potent and specific inhibitor of gamma-secretase. This reduces antibody levels in-vivo in plasma and cerebrospinal fluid. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD).

Effect

DAPT causes neural cells to commit to neuronal differentiation.

Alternative Names

N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester

References

1. Dovey, H.F., et al. 2001. J. Neurochem. 76: 173-181. PMID: 11145990

2. Geling, A., et al. 2002. EMBO Rep. 3: 688-694. PMID: 12101103

3. Lanz, T.A., et al. 2003. J. Pharmacol. Exp. Ther. 305: 864-871. PMID: 12626636

4. Gowrishankar, K., et al. 2004. J. Cell. Sci. 117: 4099-4111. PMID: 15280425

5. De Smedt, M., et al. 2005. Blood. 106: 3498-3506. PMID: 16030192

6. El Mouedden, M., et al. 2006. Curr. Pharm. Des. 12: 671-676. PMID: 16472156

Product Details
Formula C23H26F2N2O4
Molecular Weight 432.46
CAS Number 208255-80-5
Purity >99%
Solubility DMSO
Stability and Storage Stable at -20°C. Keep away from direct sunlight.