DAPT
Exact Amount™
The mg quantity of material provided in the smallest pack size for this product is specified on the vial label to two decimal places. This reduces concentration variation and ensures reproducibility in your experiments.Activity
DAPT is a potent and specific inhibitor of gamma-secretase. This reduces antibody levels in-vivo in plasma and cerebrospinal fluid. It blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD).
Effect
DAPT causes neural cells to commit to neuronal differentiation.
Alternative Names
N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester
References
1. Dovey, H.F., et al. 2001. J. Neurochem. 76: 173-181. PMID: 11145990
2. Geling, A., et al. 2002. EMBO Rep. 3: 688-694. PMID: 12101103
3. Lanz, T.A., et al. 2003. J. Pharmacol. Exp. Ther. 305: 864-871. PMID: 12626636
4. Gowrishankar, K., et al. 2004. J. Cell. Sci. 117: 4099-4111. PMID: 15280425
5. De Smedt, M., et al. 2005. Blood. 106: 3498-3506. PMID: 16030192
6. El Mouedden, M., et al. 2006. Curr. Pharm. Des. 12: 671-676. PMID: 16472156
| Product Details | |
|---|---|
| Formula | C23H26F2N2O4 |
| Molecular Weight | 432.46 |
| CAS Number | 208255-80-5 |
| Purity | >99% |
| Solubility | DMSO |
| Stability and Storage | Stable at -20°C. Keep away from direct sunlight. |
