Recombinant Human Eotaxin-1 / CCL11

Code Description Price Qty
GFH178-5 Recombinant Human Eotaxin-1 / CCL11, 5 μg £50.00
GFH178-20 Recombinant Human Eotaxin-1 / CCL11, 20 μg £120.00
GFH178-100 Recombinant Human Eotaxin-1 / CCL11, 100 μg £310.00
GFH178-100x10 Recombinant Human Eotaxin-1 / CCL11, 100 μg x 1 £1,375.00
GFH178-1000 Recombinant Human Eotaxin-1 / CCL11, 1 mg £1,375.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human Eotaxin-1 has a predicted Mw of 8.4 kDa.

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PODS Growth Factors

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Description

Eotaxin-1, also known as Eotaxin and CCL11, is a chemokine that recruits eosinophils to sites of allergic inflammation. Eotaxin-1 signals through the G protein-coupled chemokine receptors CCR2, CCR3, and CCR5. Eotaxin-1 also negatively regulates adult neurogenesis. High Eotaxin-1 levels are associated with impaired learning and memory.

Activity Assay

Human Eotaxin-1 is fully biologically active when compared to standard. The activity is determined by the ability to induce chemotaxis of primary human eosinophils starting at a concentration of 50 ng/ml. There is no data currently available.

AA Sequence

GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Alternative Names

CCL11, Eosinophil Chemotactic Protein, eotaxin, eotaxin1
Product Details
Length 74 aa
Molecular Weight 8.4 kDa
Structure Monomer
Source E. coli
Accession Number P51671
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.