Recombinant Human Myostatin / GDF-8
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DescriptionMyostatin, also known as GDF-8, a conserved member of the TGF-β superfamily, is an essential regulator of skeletal muscle mass and cardiac muscle development and function. Myostatin is a secreted protein that negatively regulates skeletal muscle growth by determining muscle fiber number and size. Myostatin binds one of the two activin type II receptors (ACTRIIA, ACTRIIB) to activate SMAD signaling. Myostatin also activates MAPK signaling through TAK1-MKK6 and Ras pathways. Inhibition of myostatin increases muscle mass in a number of human disease animal models, such as muscular dystrophy.
Activity AssayHuman Myostatin is fully biologically active when compared to standard. The activity is determined by induced cytotoxicity of MPC-11 cells and it is typically less than 50 ng/ml. This corresponds to an expected specific activity of 2.0 x 104 units/mg.
AA SequenceDFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS
Alternative NamesFibroblast Growth Factor 8, FGF8, FGF 8, androgen-induced growth factor, AIGF, heparin-binding growth factor 8, HBGF-8
|109 / 218 aa
|12.8 / 24.8 kDa
|≥95% determined by reducing and non-reducing SDS-PAGE
|≤1.00 EU/μg as measured by kinetic LAL
|Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 5 mM sodium phosphate, 50 mM soldium chloride, pH 7.5
|Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
|Stability and Storage
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.