Recombinant Human TGF-β3

Code Description Price Qty
GFH109-2 Human TGF-β3, 2 μg £55.00
GFH109-10 Human TGF-β3, 10 μg £130.00
GFH109-100 Human TGF-β3, 100 μg £485.00
GFH109-1000 Human TGF-β3, 1 mg £3,875.00
Inhibition of IL-4 induced HT-2 cell proliferation for Human TGF-β3. Cell proliferation was measured to calculate the ED50, which is as expected less than 1 ng/ml.
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human TGF-β3 has a predicted Mw of 25.7 kDa (each monomer is 12.9 kDa).

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PODS® Growth Factors

This growth factor is also available as PODS® for sustained release, see here.

Description

Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Activity Assay

Human TGF-β3 is fully biologically active when compared to standard. The activity is determined by the inhibition of IL-4 induced HT-2 cell proliferation and it is typically less than 1 ng/ml. This corresponds to an expected specific activity of 1.0 x 106 units/mg.

AA Sequence

MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCS

Alternative Names

Transforming Growth Factor β 3, TGF β 3, TGF-β-3, TGFB3, TGFβ3
Product Details
Length 113 / 226 aa
Molecular Weight 12.9 / 25.7 kDa
Structure Dimer
Source E. coli
Accession Number P10600
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation In solution on 10 mM acetic acid and 20% ethanol at a concentration of 0.25 mg/ml
Reconstitution Not applicable
Stability and Storage

12 months from date of receipt when stored at 4°C as supplied.