Recombinant Mouse IL-1 β

Code Description Price Qty
GFM68-10 Mouse IL-1 β, 10 μg $189.00
GFM68-100 Mouse IL-1 β, 100 μg $728.00
GFM68-500 Mouse IL-1 β, 500 μg $3,536.00
GFM68-1000 Mouse IL-1 β, 1 mg $6,007.00
Induced proliferation of D10S cells assay for Mouse IL-1 β. Cell proliferation was measured to calculate the ED50, which is as expected less than 15 pg/ml.

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PODS® Growth Factors

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Interleukin-1 β (IL-1 β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1 β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1 β and the independently regulated IL-1 α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.

Activity Assay

Mouse IL-1 β is fully biologically active when compared to standard. The activity is determined by the ability to induce D10S cells proliferation and it is typically less than 15 pg/ml. This corresponds to an expected specific activity of 6.7 x 107 units/mg.

AA Sequence


Alternative Names

Interleukin-1 β, preinterleukin 1 β, IL1, IL 1, catabolin, LAF, EP, LEM, MCF
Product Details
Length 154 aa
Molecular Weight 17.5 kDa
Structure Monomer
Source E. coli
Accession Number P01584
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium phosphate, pH 7.5
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.