Recombinant Mouse TGF-β3
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human TGF-β3 has a predicted Mw of 25.7 kDa (each monomer is 12.9 kDa).
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PODS® Growth Factors
The product is currently not available as PODS®, please check back in the future.Description
Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β 2, and -β 3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.Activity Assay
Mouse TGF-β3 is fully biologically active when compared to standard. The activity is determined by the inhibition of IL-4 induced HT-2 cell proliferation and it is typically less than 1 ng/ml. This corresponds to an expected specific activity of 1.0 x 106 units/mg.AA Sequence
MALDTNYCFR NLEENCCVRP LYIDFRQDLG WKWVHEPKGY YANFCSGPCP YLRSADTTHS TVLGLYNTLN PEASASPCCV PQDLEPLTIL YYVGRTPKVE QLSNMVVKSC KCSAlternative Names
Transforming Growth Factor β 3, TGF β 3, TGF-β-3, TGFB3, TGFβ3| Product Details | |
|---|---|
| Length | 113 / 226 aa |
| Molecular Weight | 12.9 / 25.7 kDa |
| Structure | Dimer |
| Source | E. coli |
| Accession Number | P10600 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | In solution on 10 mM acetic acid and 20% ethanol at a concentration of 0.25 mg/ml |
| Reconstitution | Not applicable |
| Stability and Storage |
12 months from date of receipt when stored at 4°C as supplied. |
