Recombinant Human Eotaxin-3 / CCL26
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DescriptionEotaxin-3, also known as CCL26, is a chemokine that is made by vascular endothelial and lung epithelial cells following Interleukin-4 (IL-4) or Interleukin-13 (IL-13) stimulation. Eotaxin-3 signals through the G protein-coupled chemokine receptor CCR3 to recruit eosinophils and basophils to inflammatory sites.
Activity AssayHuman Eotaxin-3 is fully biologically active when compared to standard. The activity is determined by the ability to induce chemotaxis of cell lines expressing CCR3. There is no data currently available.
AA SequenceTRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Alternative NamesCCL26, MIP-4 α, TSC-1, eotaxin3, eotaxin 3
|Molecular Weight||8.4 kDa|
|Purity||≥95% determined by reducing and non-reducing SDS-PAGE|
|Endotoxin Level||≤1.00 EU/μg as measured by kinetic LAL|
|Formulation||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)|
|Reconstitution||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Stability and Storage||
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.