Recombinant Human GDF-15 (Animal-Free)

Code Description Price Qty
GFH171AF-5 Human GDF-15 (Animal-Free), 5 μg $70.00
GFH171AF-20 Human GDF-15 (Animal-Free), 20 μg $180.00
GFH171AF-100 Human GDF-15 (Animal-Free), 100 μg $510.00
GFH171AF-1000 Human GDF-15 (Animal-Free), 1 mg $4,205.00
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human GDF-15 has a predicted Mw of 24.8 kDa (each monomer is 12.4 kDa).

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PODS® Growth Factors

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Animal-Free

This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.

Description

Growth Differentiation Factor 15 (GDF-15) is a member of the Transforming Growth Factor β (TGF-β) family and is made by the placenta and cardiovascular tissues. GDF-15 regulates inflammatory and apoptotic pathways during cellular stress and injury. GDF-15 is emerging as a biomarker of early heart disease, such that increased levels of circulating GDF-15 are associated with an increased risk of developing heart failure.

Activity Assay

Activity to be determined.

AA Sequence

MARNGDHCPL GPGRCCRLHT VRASLEDLGW ADWVLSPREV QVTMCIGACP SQFRAANMHA QIKTSLHRLK PDTVPAPCCV PASYNPMVLI QKTDTGVSLQ TYDDLLAKDC HCI

Alternative Names

Growth Differentiation Factor 15, GDF15, GDF 15, MIC-1, placental TGF β, prostate differentiation factor
Product Details
Length 113 / 226 aa
Molecular Weight 12.4 / 24.8 kDa
Structure Dimer
Source E. coli
Accession Number Q99988
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.