Recombinant Human GRO-β / CXCL2

Code Description Price Qty
GFH123-2 Human GRO-β, 2 μg $65.00
GFH123-10 Human GRO-β, 10 μg $165.00
GFH123-100 Human GRO-β, 100 μg $410.00
GFH123-1000 Human GRO-β, 1 mg $2,950.00
Induced chemotaxis of human neutrophils assay for Human GRO-β.
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human GRO-β has a predicted Mw of 7.9 kDa.

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Description

Growth regulated protein β (GRO-β), also known as CXCL2, is a chemokine that is secreted by macrophages, neutrophils, and monocytes at sites of inflammation. GRO-β functions as a chemoattractant for leukocytes and hematopoietic stem cells. GRO-β activity is mediated through binding the G-protein-coupled chemokine receptor CXCR2.

Activity Assay

Human GRO-β is fully biologically active when compared to standard. The activity is determined by the induced chemotaxis of human neutrophils.

AA Sequence

APLATELRCQ CLQTLQGIHL KNIQSVKVKS PGPHCAQTEV IATLKNGQKA CLNPASPMVK KIIEKMLKNG KSN

Alternative Names

Growth regulated protein β, GROb, GROb1, CXCL2, MGSAβ, MGSA β, MGSA-b, CXCL2, MIP-2 α, MIP-2a, MIP2-α, MIP2A, MIP22, GRO2, chemokine (C-X-C motif) ligand 2, C-X-C motif chemokine 2, SCYB2, melanoma growth stimulatory activity β, CINC-2a, GROB3, GRO2 oncogene, macrophage inflammatory protein 2 α
Product Details
Length 73 aa
Molecular Weight 7.9 kDa
Structure Monomer
Source E. coli
Accession Number P19875
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.