Recombinant Human IGF-2 (Animal-Free)
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PODS® Growth Factors
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Animal-Free
This product is produced with no animal derived raw products. All processing and handling employs animal free equipment and animal free protocols.
Description
Insulin-like Growth Factor 2 (IGF-2) is an important fetal growth hormone made by theca cells during gestation. IGF-2 engages the IGF-1 receptor (IGF1R) to mediate embryonic growth. IGF-2 also binds the sink IGF-2 receptor (IGF2R) leading to IGF-2 degradation.
Activity Assay
Human IGF-2 (Animal-Free) is fully biologically active when compared to standard. rh IGF-2 activity is tested in human breast cancer cell line MCF-7, with Acceptance Criteria ED50 of less than or equal to 6ng/mL.
AA Sequence
AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE
Alternative Names
Insulin-like Growth Factor 2, somatamedin A, IGF-II
| Product Details | |
|---|---|
| Length | 67 aa |
| Molecular Weight | 7.5 kDa |
| Structure | Monomer |
| Source | E. coli |
| Accession Number | P01344 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Reconstitution | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Stability and Storage |
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. |
