Recombinant Human IL-11

Code Description Price Qty
GFH84-2 Human IL-11, 2 μg $65.00
GFH84-10 Human IL-11, 10 μg $165.00
GFH84-100 Human IL-11, 100 μg $635.00
GFH84-1000 Human IL-11, 1 mg $5,240.00
Induced proliferation of T11 cells for Human IL-11. Cell proliferation was measured to calculate the ED50, which is as expected less than 2.5 ng/ml.
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human IL-11 has a predicted Mw of 19.3 kDa.

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Description

Interleukin-11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling. Human IL-11 shows activity on mouse cells.

Activity Assay

Human IL-11 is fully biologically active when compared to standard. The activity is determined by the ability to induce T11 cells proliferation and it is typically less than 2.5 ng/ml. This corresponds to an expected specific activity of 4 x 105 units/mg.

AA Sequence

MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Alternative Names

Interleukin-11, interleukin 11, IL11, IL 11
Product Details
Length 179 aa
Molecular Weight 19.3 kDa
Structure Monomer
Source E. coli
Accession Number P20809
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile 10 mM HCI at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.