Recombinant Human IL-17E / IL-25
Induced IL-8 production by human PBMC cells when cultured with Human IL-17E.
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PODS® Growth Factors
The product is currently not available as PODS®, please check back in the future.Description
Interleukin-17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17BR receptor to stimulate the secretion of the proinflammatory Interleukin-8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB).Activity Assay
Human IL-17E is fully biologically active when compared to standard. The activity is determined by the ability to produce IL-8 by human PBMC cells.AA Sequence
MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGTAlternative Names
Insulin-like Growth Factor 1, somatamedin C, mechano growth factor, IGF-IA, IGF-IB, IGF-I, IGFI, insulin-like growth factor I, IGF1A1, insulin-like growth factor IA, insulin-like growth factor IB, MGF2, IBP1| Product Details | |
|---|---|
| Length | 146 / 292 aa |
| Molecular Weight | 16.9 / 33.7 kDa |
| Structure | Dimer |
| Source | E. coli |
| Accession Number | Q9H293 |
| Purity | ≥95% determined by reducing and non-reducing SDS-PAGE |
| Endotoxin Level | ≤1.00 EU/μg as measured by kinetic LAL |
| Formulation | Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA) |
| Reconstitution | Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Stability and Storage |
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. |
