Recombinant Human IL-17F

Code Description Price Qty
GFH152-5 Human IL-17F, 5 μg $75.00
GFH152-25 Human IL-17F, 25 μg $189.00
GFH152-100 Human IL-17F, 100 μg $469.00
GFH152-1000 Human IL-17F, 1 mg $3,382.00
Induced production of Mouse IL-6 by 3T3 cells when cultured with Human IL-17F.

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Interleukin-17F (IL-17F), a member of the IL-17 cytokine family, is secreted by activated CD4+ T cells and monocytes. IL-17F binds the IL-17 receptor related molecule, IL17RC, to promote the production of the interleukin-6 (IL-6), interleukin-8 (IL-8), and Granulocyte Macrophage Colony-Stimulating Factor (GM-CSF) cytokines. IL-17F also functions to regulate matrix turnover rates, inhibit endothelial cell angiogenesis, and induce the endoethelial cell expression of interleukin-2 (IL-2), Monocyte Chemoattractant Protein 1 (MCP-1), and Transforming Growth Factor β 1 (TGF-β1).

Activity Assay

Human IL-17F is fully biologically active when compared to standard. The activity is determined by the ability to produce mouse IL-6 by 3T3 cells and it is typically less than 100 ng/ml. This corresponds to an expected specific activity of 1 x 104 units/mg.

AA Sequence


Alternative Names

Interleukin-17F, interleukin 17F, IL17F, IL 17F
Product Details
Length 134 / 268 aa
Molecular Weight 15.0 / 30.0 kDa
Structure Dimer
Source E. coli
Accession Number Q96PD4
Purity ≥95% determined by reducing and non-reducing SDS-PAGE
Endotoxin Level ≤1.00 EU/μg as measured by kinetic LAL
Formulation Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Reconstitution Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.
Stability and Storage

12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.