Recombinant Human IL-19
Non-reducing (-) and reducing (+) conditions in a 4 - 20% Tris-Glycine gel stained with Coomassie Blue. 1 μg of protein was loaded in each lane. Human IL-19 has a predicted Mw of 17.9 kDa.
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DescriptionInterleukin-19 (IL-19) is a member of the interleukin-10 (IL-10) cytokine family and is produced by B cells and monocytes. IL-19 binds the interleukin-20 receptor complex (IL-20R) to activate STAT3 signaling. IL-19 induces interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF-α) expression in monocytes, and promotes T helper 2 (Th2) cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
Activity AssayActivity to be determined.
AA SequenceMLRRCLISTD MHHIEESFQE IKRAIQAKDT FPNVTILSTL ETLQIIKPLD VCCVTKNLLA FYVDRVFKDH QEPNPKILRK ISSIANSFLY MQKTLRQCQE QRQCHCRQEA TNATRVIHDN YDQLEVHAAA IKSLGELDVF LAWINKNHEV MFSA
Alternative NamesInterleukin-19, interleukin 19, IL19, IL 19, melanoma differentiation associated-like protein
|Molecular Weight||17.9 kDa|
|Purity||≥95% determined by reducing and non-reducing SDS-PAGE|
|Endotoxin Level||≤1.00 EU/μg as measured by kinetic LAL|
|Formulation||Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)|
|Reconstitution||Centrifuge vial before opening. When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at 0.1 mg/ml, which can be further diluted into other aqueous solutions.|
|Stability and Storage||
12 months from date of receipt when stored at -20°C to -80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed.